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GW21068

Sigma-Aldrich

Anti-MAP2K1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Dual specificity mitogen-activated protein kinase kinase 1, Anti-MEK1, Anti-Mitogen-activated protein kinase kinase 1

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About This Item

MDL number:
MFCD00239713
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, rat, human

manufacturer/tradename

Genway 15-288-21068

technique(s)

western blot: suitable

NCBI accession no.

NP_002746.1

UniProt accession no.

Q02750

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAP2K1(5604)

Immunogen

Immunogen Sequence: GI # 5579478, sequence 1-28
Recombinant mitogen-activated protein kinase kinase 1

Application

Anti-MAP2K1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Biochem/physiol Actions

Dual specificity mitogen-activated protein kinase kinase 1 is an enzyme encoded by the MAP2K1 gene in humans and its signaling is one of the most important mechanisms for the cytoplasmic transduction of extracellular signals. MAP2K1 is mapped between chromosomes 15q22.1 and q22.33. It is induced with G2 phase MAPK pathway activation. MAP2K1 is associated with extracellular signal regulated kinases pathway and is involved in regulation of multiple cellular processes that include the cell cycle. Its inhibitors can partially modulate the expression of interferon-stimulated genes.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
029K2266

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Tanya Pike et al.
Cellular signalling, 25(6), 1423-1428 (2013-03-26)
The primary endpoint of signalling through the canonical Raf-MEK-ERK MAP kinase cascade is ERK activation. Here we report a novel signalling outcome for this pathway. Activation of the MAP kinase pathway by growth factors or phorbol esters during G2 phase
Rongjuan Pei et al.
Virologica Sinica, 27(5), 278-285 (2012-09-25)
The mitogen activated protein kinases-extracellular signal regulated kinases (MAPK-ERK) pathway is involved in regulation of multiple cellular processes including the cell cycle. In the present study using a Huh7 cell line Con1 with an HCV replicon, we have shown that
L Rampoldi et al.
Cytogenetics and cell genetics, 78(3-4), 301-303 (1997-01-01)
The mitogen-activated protein kinase (MAPK) signaling cascade is one of the most important mechanisms for the cytoplasmic transduction of extracellular signals. We report the chromosomal localization of the human MEK1, MEK3, MEK4 and MEKK5 genes, involved in the MAPK cascade.

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