GW21051
Anti-CX3CR1 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-CX3C chemokine receptor 1
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About This Item
biological source
chicken
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
manufacturer/tradename
Genway 15-288-21051
technique(s)
indirect ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CX3CR1(1524)
General description
CX3CR1 (chemokine (C-X3-C motif) receptor 1) is a surface receptor for chemoattractant cytokines. It is expressed by circulating monocytes, tissue macrophages and dendritic cells, T cells and natural killer (NK) cells. It acts as a receptor for CX3CL1 chemokine.[1] In brain, it is expressed only in microglial cells.
Immunogen
Immunogen Sequence: GI # 4503171, sequence 1-21
Recombinant chemokine (C-X3-C motif) receptor 1
Application
Anti-CX3CR1 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
CX3C chemokine receptor 1 (CX3CR1) plays an important role in modulating inflammatory responses that includes monocyte homeostasis and macrophage phenotype and function. CX3CR1 is associated with angiogenic macrophage survival in the tumor microenvironment contributing to tumor metastasis.[1] It is implicated as a candidate gene for age-related macular degeneration (AMD). CX3CR1 polymorphisms may influence the incidence and the outcome of acute myocardial infarction.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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S Pucci et al.
BioMed research international, 2013, 451349-451349 (2013-12-07)
Fractalkine is a proinflammatory chemokine that participates in atherosclerotic process mediating the interactions of vascular cells and leukocytes and selective recruitment of Th1 lymphocytes, through interaction with CX3CR1 receptor. The polymorphism of the fractalkine receptor 280M-containing haplotype, which codifies for
Jiao Zheng et al.
Molecular cancer, 12(1), 141-141 (2013-11-20)
Macrophages, the key component of the tumor microenvironment, are differentiated mononuclear phagocyte lineage cells that are characterized by specific phenotypic characteristics that have been implicated in tumor growth, angiogenesis, and invasion. CX3CR1, the chemoattractant cytokine CX3CL1 receptor, plays an important
Alan Lopez-Lopez et al.
PloS one, 9(5), e96528-e96528 (2014-05-09)
The objective of this study was to investigate the association of functional variants of the human CX3CR1 gene (Fractalkine receptor) with the risk of Amyotrophic Lateral Sclerosis (ALS), the survival and the progression rate of the disease symptoms in a
Debra A Schaumberg et al.
JAMA ophthalmology, 132(1), 84-95 (2013-11-30)
The CX3CR1 gene is implicated as a candidate gene for age-related macular degeneration (AMD) through several lines of evidence. There is uncertainty, however, as to whether common genetic variants in CX3CR1 alter risk of AMD, since prior studies have been
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