GW21046

Anti-CCR2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Chemokine (C-C motif) receptor 2 isoform A, Anti-MCP-1 receptor
• MDL number: MFCD01864606
• UNSPSC Code: 12352203

Properties

• biological source: chicken
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• manufacturer/tradename: Genway 15-288-21046
• technique(s): western blot: suitable
• NCBI accession no.: NP_000638.1
• UniProt accession no.: O95950
• shipped in: wet ice
• storage temp.: −20°C
• Gene Information: human ... CCR2(1231)

Description

General description

CCR2 (chemokine (C-C motif) receptor 2) belongs to the chemokine receptor family, which are small (8-10kDa) G-protein coupled receptors (GPCR). This family is subdivided into four families called CC, CXC, CX3C and XC. CCR2 belongs to the CC family, and has its ligand-binding domain in its exoplasmic N-terminal. Its C-terminal is involved in intracellular signaling. It is constitutively expressed by monocytes, and is found on T-cells, naïve B-cells, NK (natural killer) cells, dendritic cells and basophils.

Immunogen

Immunogen Sequence: GI # 4502633, sequence 1-45

Recombinant chemokine (C-C motif) receptor 2 isoform A

Application

Anti-CCR2 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
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Biochem/physiol Actions

C-C chemokine receptor type 2 (CCR2) is an important chemokine for monocyte aggregation and transendothelial monocyte migration. CCR2 plays an important role in extravasation and transmigration of monocytes under inflammatory conditions. It is involved in the growth and invasion of prostate cancer (PCa). CCR2 expression is very important for CCL2-induced proliferation and invasion of PC-3M cells. CCR2 can also act as a promising molecular target for prevention of PCa growth and metastasis.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)