Immunogen Sequence: GI # 46575632, sequence 33-111
Recombinant interleukin 21
Application
Anti-Interleukin-21 antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Interleukin-21 (IL-21) is a protein encoded by the IL21 gene in humans. It is a cytokine that has potent regulatory effects on cells of the immune system, including natural killer (NK) cells and cytotoxic T cells. Cytokines are crutial for the regulation of haematopoiesis and immune responses. It can influence lymphocyte development. IL21 has an important role in the proliferation and maturation of natural killer (NK) cell populations from bone marrow. The gene may play a role in the development of Systemic lupus erythematosus (SLE). IL-21 is essential for B cell activation, expansion and PC differentiation induced by direct interaction of B cells with activated T cells. Polymorphisms of this gene is associated with several cancers.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Systemic lupus erythematosus (SLE) is one of the common autoimmune diseases, with complex genetic components. Interleukin-21 (IL-21) is the most recently discovered member of the type-I cytokine family, which has a variety of effects on the immune system, including B
Polymorphisms in Interleukin (IL)-21 have been researched in several cancers, but the association between IL-21 polymorphisms and thyroid cancer remains unclarified. This case-control study explored the role of five tagSNPs (rs12508721C>T, rs907715G>A, rs13143866G>A, rs2221903A>G and rs4833837A>G) in IL-21 gene in
Journal of immunology (Baltimore, Md. : 1950), 179(9), 5886-5896 (2007-10-20)
During T cell-B cell collaboration, plasma cell (PC) differentiation and Ig production are known to require T cell-derived soluble factors. However, the exact nature of the cytokines produced by activated T cells that costimulate PC differentiation is not clear. Previously
Cytokines are important in the regulation of haematopoiesis and immune responses, and can influence lymphocyte development. Here we have identified a class I cytokine receptor that is selectively expressed in lymphoid tissues and is capable of signal transduction. The full-length
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