KCNC2 (potassium channel, voltage gated subfamily C, member 2) is a voltage gated K+ channel, which is a member of the Shaw family of K+ channels (haas). This gene is localized to human chromosome 12q21.
Immunogen
Immunogen Sequence: GI # 21217563, sequence 483-638
Recombinant shaw-related voltage-gated potassium channel protein 2 isoform KV3.2b
Application
Anti-KCNC2 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
KCNC2 (potassium voltage-gated channel subfamily C member 2) is essential for the generation of action potentials in neurons, at high frequency. It also has a novel role at developmental stage and is expressed in embryonic stage. This gene might be involved in the pathology of neurological diseases, as deletion in this gene location is associated with ataxia and delay in neurodevelopment.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Journal of neurology, neurosurgery, and psychiatry, 84(11), 1255-1257 (2013-03-12)
To describe the clinical and genetic findings in a family affected by neurodevelopmental delay and cerebellar ataxia. The affected mother and her two children underwent clinical assessments followed by radiological, neurophysiological and cytogenetic investigations. All three affected members exhibited varying
Journal of molecular neuroscience : MN, 46(3), 606-615 (2011-09-14)
In neurons, voltage-dependent Kv3 potassium channels are essential for the generation of action potentials at high frequency. A dysregulation of the Kv3.1 and Kv3.4 channel subunits has been suggested to contribute to neuronal and glial alterations in Alzheimer's disease, but
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