Recombinant charged multivesicular body protein 1/chromatin modifying protein 1
Application
Anti-PCOLN3 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Charged multivesicular body protein 1a is a protein encoded by the CHMP1A gene in humans and is a member of the ′Endosomal Sorting Complex Required for Transport′ (ESCRT-III) family. It plays a role in the cytoplasm in sorting proteins to the multivesicular body (MVB) and functions as a tumor suppressor gene in renal cells. It may be a useful target for treatment of renal cell carcinoma (RCC). Overexpression of this gene induces growth inhibition, chromatin condensation and p53 phosphorylation. The gene regulates Ataxia telangiectasia mutated (ATM) and the nuclear localization signal (NLS) that is required for ATM activation. It also regulates tumor growth partly through ATM signaling. It is a novel tumor suppressor, especially in pancreas and regulates tumor growth potentially through p53 signaling pathway. It also plays a role in stable gene silencing within the nucleus.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
Chmp1A (Chromatin modifying protein 1A/Charged multivesicular protein 1A) is a member of the ESCRT-III (Endosomal Sorting Complex Required for Transport) family that was shown to function in endosome-mediated trafficking via multivesicular body (MVB) formation and sorting. Recent reports suggest that
Journal of cell science, 114(Pt 13), 2383-2393 (2001-09-18)
The Polycomb-group (PcG) is a diverse set of proteins required for maintenance of gene silencing during development. In a screen for conserved partners of the PcG protein Polycomblike (Pcl), we have identified a new protein, human CHMP1 (CHromatin Modifying Protein;
Renal cell carcinoma (RCC) is a highly malignant and often fatal disease of the kidney. Chmp1A is a member of the Endosomal Sorting Complex Required for Transport (ESCRT-III) family, and plays a role in the cytoplasm in sorting proteins to
Chromatin modifying protein 1A (Chmp1A) is a member of the Endosormal sorting complex required for transport (ESCRT)-III family whose over-expression induces growth inhibition, chromatin condensation, and p53 phosphorylation. p53 is a substrate for Ataxia telangiectasia mutated (ATM), which can be
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