Immunogen Sequence: GI # 4885425, sequence 116-189
Recombinant V-Ha-ras Harvey rat sarcoma viral oncogene homolog isofrom 1
Application
Anti-HRAS antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
GTPase HRas is an enzyme encoded by the HRAS gene in humans. It is located on the short (p) arm of chromosome 11 at position 15.5. Somatic mutation of this gene is restricted to a specific proportion of sporadic pheochromocytoma (PCC). It is strictly monomeric at comparable densities in solution and dimerization is a general property of native H-Ras on membrane surfaces. Missense mutation in the HRAS gene causes an autosomal-dominant syndrome, Costello syndrome.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
The Journal of clinical endocrinology and metabolism, 99(7), E1376-E1380 (2014-04-02)
Somatic or germline mutations in up to 15 disease-causative genes are detectable in up to 50% of patients with pheochromocytoma (PCC) and paraganglioma (PGL). Very recently, somatic H-RAS mutations were identified by exome sequencing in approximately 7% in sporadic PCCs
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 17(6), 421-430 (2014-08-19)
Costello syndrome is a rare, autosomal-dominant syndrome caused by activating missense mutations in the Harvey rat sarcoma viral oncogene homolog (HRAS), most often p.G12S. Several rare mutations have consistently been associated with a more severe phenotype that is often lethal
Proceedings of the National Academy of Sciences of the United States of America, 111(8), 2996-3001 (2014-02-12)
The lipid-anchored small GTPase Ras is an important signaling node in mammalian cells. A number of observations suggest that Ras is laterally organized within the cell membrane, and this may play a regulatory role in its activation. Lipid anchors composed
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