Anti-Human IgA antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biochem/physiol Actions
Ig α-1 chain C region is a protein encoded by the IGHA1 gene in humans. IgA deficiency (IgAD) is the most common immunodeficiency and it has 2 subclasses, they are IgA1 and IgA2. Its heavy chains are encoded by the α1 and α2 genes. Galactose-deficient IgA1 (GdIgA1) has an important role in the pathogenesis of IgA nephropathy (IgAN). It can act as a useful non-invasive IgAN biomarker. Immunoglobulin A nephropathy (IgAN) is associated with genetic as well as environmental factors and undergalactosylation of IgA1 in the serum may contributor to pathogenesis of IgAN.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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Recent studies have shown that galactose-deficient IgA1 (GdIgA1) has an important role in the pathogenesis of IgA nephropathy (IgAN). Although emerging data suggest that serum GdIgA1 can be a useful non-invasive IgAN biomarker, the localization of nephritogenic GdIgA1-producing B cells
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 24(11), 3372-3375 (2009-06-18)
Immunoglobulin A nephropathy (IgAN) is associated with genetic and environmental factors, and undergalactosylation of IgA1 in the serum is considered to be a contributor to pathogenesis of IgAN. The present study was conducted to detect the galactose- (Gal) deficient IgA1
Allergology international : official journal of the Japanese Society of Allergology, 58(1), 111-117 (2009-01-21)
IgA deficiency (IgAD) is the most common immunodeficiency, however the pathogenesis in most cases of IgAD is unknown. There are 2 subclasses of IgA, IgA1 and IgA2, and its heavy chains are encoded by 2 different genes, the alpha1 and
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