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GW10807F

Anti-GAG polyprotein antibody produced in chicken

Name: Anti-GAG polyprotein antibody produced in chicken
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-GAG_HV1N5, Anti-Gag polyprotein

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

viral

manufacturer/tradename

Genway 15-288-10807F

technique(s)

western blot: suitable

NCBI accession no.

AAK08483.1

UniProt accession no.

P12493

shipped in

wet ice

storage temp.

−20°C

Gene Information

human immunodeficiency virus 1 ... Gag(155030)

Immunogen

Immunogen Sequence: GI # 12831136, sequence 2-132

Recombinant gag polyprotein (HIV-1 vector pNL4-3)

Application

Anti-GAG polyprotein antibody produced in chicken is suitable for western blot analysis.

Biochem/physiol Actions

GAG is highly involved in RNA trafficking. It helps in transport of human immunodeficiency virus type 1 (HIV-1) RNA via diffusion within the cytoplasm. Ubiquitination of Gag enhances possibilities of its optimal function in virus release and maturation. It also recruits Ub ligases at the viral assembly site.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein.

Jianbo Chen et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(48), E5205-E5213 (2014-11-19)

Full-length HIV-1 RNA plays a central role in viral replication by serving as the mRNA for essential viral proteins and as the genome packaged into infectious virions. Proper RNA trafficking is required for the functions of RNA and its encoded

Proteasome inhibition interferes with gag polyprotein processing, release, and maturation of HIV-1 and HIV-2.

U Schubert et al.

Proceedings of the National Academy of Sciences of the United States of America, 97(24), 13057-13062 (2000-11-23)

Retrovirus assembly and maturation involve folding and transport of viral proteins to the virus assembly site followed by subsequent proteolytic cleavage of the Gag polyprotein within the nascent virion. We report that inhibiting proteasomes severely decreases the budding, maturation, and

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