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GW10735F

Sigma-Aldrich

Anti-Erythropoietin antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-EPO, Anti-MGC138142

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About This Item

MDL number:
MFCD02096326
UNSPSC Code:
12352203

biological source

chicken

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, mouse, rat

manufacturer/tradename

Genway 15-288-10735F

technique(s)

indirect ELISA: suitable
western blot: suitable

NCBI accession no.

NP_000790.1

UniProt accession no.

P01588

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... EPO(2056)

General description

EPO (erythropoietin) encodes a protein belonging to the cytokine type I superfamily. It is a secreted, glycosylated cytokine that contains four α−helical bundles.

Immunogen

Immunogen Sequence: GI # 4503589, sequence 1-193
Recombinant erythropoietin

Application

Anti-Erythropoietin antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for cell staining at a working dilution of 1:200. It is also suitable for ELISA.

Biochem/physiol Actions

Erythropoietin (EPO) promotes erythroid differentiation and hemoglobin synthesis and is involved in the regulation of red cell production. It exhibits neuroprotective activity against several potential brain injuries. In immature erythroid cells, EPO binds to its receptor (EPOR) and represses apoptosis, promotes cell proliferation and differentiation into mature erythrocytes. Presence of EPO induces proliferation and invasion of bladder cancer cells. It is also up-regulated in uterine leiomyoma. Under hypoxia, EPO is up-regulated. EPO levels are higher in humans suffering from thalassemia.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
118K1809
029K2183
118K18091

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Ryoko Asano et al.
American journal of obstetrics and gynecology, 213(2), 199-199 (2015-03-01)
Myomatous erythrocytosis syndrome is a rare complication of uterine leiomyoma caused by erythropoietin (EPO) that is produced by tumor cells. We assessed the EPO expression in leiomyomas and investigated the effects of EPO on the tumor growth. Tissue samples were
Erythropoietin and the control of red cell production.
S E Graber et al.
Annual review of medicine, 29, 51-66 (1978-01-01)
P Ghezzi et al.
Cell death and differentiation, 11 Suppl 1, S37-S44 (2004-07-10)
Erythropoietin (EPO) increases the number of circulating erythrocytes primarily by preventing apoptosis of erythroid progenitors. In addition to this proerythroid action, results of recent studies show that systemically administered EPO is protective in vivo, in several animal models of neuronal
Sung Lyea Park et al.
Oncology reports, 32(5), 2207-2214 (2014-09-02)
Erythropoietin (EPO) is a cytokine that modulates the production of red blood cells. Previous studies have contradicted the assumed role of EPO in tumor cell proliferation. In the present study, we investigated the effect of EPO in the proliferation, migration and
Erythropoietin structure-function relationships.
J P Boissel et al.
Progress in clinical and biological research, 352, 227-232 (1990-01-01)
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