Anti-Somatotropin antibody produced in chicken is suitable for western blotting at a working dilution of 1:500 and for indirect ELISA.
Biochem/physiol Actions
Somatotropin is essential for growth control by stimulating the liver and other tissues to secrete IGF-1. Mutations in this gene causes deficiency of growth hormone and results in dwarfism.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide.
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The diverse roles of IGF-1 in physiology include acting as the endocrine intermediate to elicit the anabolic actions of GH. The majority of serum IGF-1 is synthesized in liver, where GH stimulates Igf1 gene transcription via the transcription factor, signal
A new mutation causing inherited growth hormone deficiency: a compound heterozygote of a 6.7 kb deletion and a two base deletion in the third exon of the GH-1 gene.
Y Igarashi et al.
Human molecular genetics, 2(7), 1073-1074 (1993-07-01)
Subtle mutations in the growth hormone 1 (GH1) gene have been regarded as a comparatively rare cause of short stature. Such lesions were sought in a group of 41 individuals selected for short stature, reduced height velocity, and bone age
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