G9790
Anti-Glutamate Receptor 2/3, Metabotropic (mGluR2/3) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, feline, mouse
technique(s)
immunohistochemistry (frozen sections): 1:500
immunoprecipitation (IP): 1:100
indirect immunofluorescence: 1:500
western blot: 1:1,000
UniProt accession no.
shipped in
dry ice
Storage temp.
−20°C
Gene Information
mouse ... Grm2(108068)
rat ... Grm2(24415)
General description
The metabotropic glutamate receptors consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Glutamate is the main excitatory neurotransmitter in the brain. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors, involved in the fast excitatory synaptic transmission. Glutamate also regulates ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins, called metabotropic glutamate receptors.
Specificity
This antibody recognizes the C-terminal sequence shared by metabotropic glutamate receptors 2 and 3.
Immunogen
synthetic peptide corresponding to the C-terminal region (13 amino acids) of mGluR2/3.
Application
Anti-Glutamate Receptor 2/3, Metabotropic (mGluR2/3) antibody produced in rabbit is suitable for immunohistochemistry and indirect immunofluorescence at a working dilution of 1:500. It is suitable for immunoprecipitation at 1:100 and for immunoblotting at 1:1000 working dilution.
Biochem/physiol Actions
GRM2 and GRM3 belong to group II receptors and are involved in the inhibition of the cyclic AMP cascade. The role of the metabotropic receptors in pain and pathology is being studied for therapeutic potential. Glutamate receptors are key regulators of excitatory amino acid neurotransmission in the striatum.
Physical form
Solution in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100μg/mL BSA, and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
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A Makoff et al.
Brain research. Molecular brain research, 40(1), 55-63 (1996-08-01)
A human brain cDNA library was screened using amplified human metabotropic glutamate receptor (mGluR) cDNA sequences as probes. The resulting clones included one containing the complete coding sequence of mGluR3. This sequence has 90% DNA sequence identity with rat mGluR3
Carla Letizia Busceti et al.
eNeuro, 11(8) (2024-07-06)
Cognitive dysfunction is associated with methamphetamine use disorder (MUD). Here, we used genetic and pharmacological approaches to examine the involvement of either Group 2 metabotropic glutamate (mGlu2) or mGlu3 receptors in memory deficit induced by methamphetamine in mice. Methamphetamine treatment
P J Flor et al.
The European journal of neuroscience, 7(4), 622-629 (1995-04-01)
A cDNA encoding the human metabotropic glutamate receptor type 2 (hmGluR2) was isolated from human brain cDNA libraries by cross-hybridization with rat mGluR2 probes. The deduced amino acid sequence of the human mGluR2 receptor consists of 872 residues and shows
W Spooren et al.
Behavioural pharmacology, 14(4), 257-277 (2003-07-03)
Following the molecular cloning in the early 1990s of the metabotropic glutamate receptors (mGlu1-8), research that focused on the physiology, pharmacology and function of these receptors revealed their potential role in CNS disorders. Numerous psychiatric and neurological dis-orders are indeed
J P Pin et al.
Neuropharmacology, 34(1), 1-26 (1995-01-01)
Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to
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