G9419
Anti-GABAA Receptor (β1 subunit), Cytosolic Loop antibody produced in rabbit
~0.2 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-γ-Aminobutyric Acid Type A Receptor (β1 subunit)
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
usage
sufficient for 10 blots
mol wt
antigen apparent mol wt 51-54 kDa
species reactivity
rat
concentration
~0.2 mg/mL
technique(s)
western blot: 1:1,000 using rat membrane fraction
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
rat ... Gabrb1(25450)
General description
GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes. GABAA receptor is a ligand-gated chloride channel that is a multimeric subunit complex. So far, around 16 subunits have been identified. This gene encodes the β1 subunit, which maps to human chromosome 4p12. It is present in a cluster along with genes encoding α 4, α 2 and γ 1 subunits of the GABA A receptor.
Immunogen
fusion protein with the amino acid sequence representing the cytosolic loop of the rat GABAA receptor (β1 subunit)
Application
Anti-GABAA Receptor (β1 subunit), Cytosolic Loop antibody produced in rabbit is suitable for western blotting at a working dilution of 1:1000 using rat membrane fraction.
Biochem/physiol Actions
The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. Disruption in this receptor is implicated in autism. Alterations in N-glycosylation of α1, β1, and β2 have been observed in schizophrenic patients.
Physical form
Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
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Kizzy Vasquez et al.
Advances in experimental medicine and biology, 775, 101-109 (2013-02-09)
Autism contains a spectrum of behavioral and cognitive disturbances of childhood development that is manifested by deficits in social interaction, impaired communication, repetitive behavior, and/or restricted interest. Much research has been dedicated to finding the genes that are responsible for
Toni Marie Mueller et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 39(3), 528-537 (2013-08-07)
The molecular mechanisms of schizophrenia have been under investigation for decades; however, the exact causes of this debilitating neuropsychiatric disorder are still unknown. Previous studies have identified multiple affected neurotransmitter systems, brain regions, and cell types, each making a unique
P J McLean et al.
Genomics, 26(3), 580-586 (1995-04-10)
We demonstrated previously that an alpha 1-beta 2-gamma 2 gene cluster of the gamma-aminobutyric acid (GABAA) receptor is located on human chromosome 5q34-q35 and that an ancestral alpha-beta-gamma gene cluster probably spawned clusters on chromosomes 4, 5, and 15. Here
D B Pritchett et al.
Nature, 338(6216), 582-585 (1989-04-13)
Neurotransmission effected by GABA (gamma-aminobutyric acid) is predominantly mediated by a gated chloride channel intrinsic to the GABAA receptor. This heterooligomeric receptor exists in most inhibitory synapses in the vertebrate central nervous system (CNS) and can be regulated by clinically
International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.
E A Barnard et al.
Pharmacological reviews, 50(2), 291-313 (1998-07-02)
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