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Key Documents

G8798

Sigma-Aldrich

β-Glucosidase, thermostable

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

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About This Item

CAS Number:
9001-22-3
UNSPSC Code:
12352204

recombinant

expressed in E. coli

assay

≥90% (SDS-PAGE)

form

liquid

specific activity

≥24 units/mg protein

mol wt

53 kDa

concentration

19-21 mg protein/mL (UV)

shipped in

wet ice

storage temp.

2-8°C

Application

β-Glucosidase is a lysosomal enzyme which breaks β1→4 bonds that link oligosaccharides. β-Glucosidase is used to study Gaucher disease and potential treatments such as enzyme replacement therapy [1].

Biochem/physiol Actions

A deficiency of β-Glucosidase results in Gaucher disease, which is the most prevalent lysosomal storage disorder. Acid β-Glucosidase cleaves the β-Glucosidase bond of it substrates, which are intermediates of globoside and ganglioside catabolism[1]. Product G8798 exhibits exo-cellulase, β-xylosidase and β-glucosidase activities and does not possess endo-xylanase, arabinoxylanase or β-glucanase activities.

Unit Definition

One unit will produce 1 μmole of o-nitrophenol from 2-nitrophenyl β-D-glucopyranoside per minute at pH 5.8 at 70 °C.

Physical form

Supplied as a solution in 50 mM Tris-HCl, pH 7.5, 100 mM NaCl, and 25% glycerol.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H334

Hazard Classifications

Resp. Sens. 1

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
SLBP7213V
SLBP3930V
SLBK1199V
SLBH5592V
SLBG1390V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

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  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the source organism of the β-Glucosidase expressed by E. coli for product G8798?

    The recombinant β-Glucosidase which is being expressed by E. coli for product G8798 is from a Bacillus species.

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    Ask a Scientist here.

Immunoquantification of beta-glucosidase: diagnosis and prediction of severity in Gaucher disease.
Maria Fuller et al.
Clinical chemistry, 51(11), 2200-2202 (2005-09-24)
Ju-Young Park et al.
Plant physiology, 149(1), 474-486 (2008-11-07)
Magnaporthe oryzae is a hemibiotrophic fungal pathogen that causes rice (Oryza sativa) blast. Although M. oryzae as a whole infects a wide variety of monocotyledonous hosts, no dicotyledonous plant has been reported as a host. We found that two rice

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