G8043
Anti-phospho-Growth Associated Protein-43 (pSer41) antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-phospho-GAP-43 (pSer41)
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About This Item
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 43 kDa
species reactivity
mouse, rat, human
technique(s)
western blot: 1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... GAP43(2596)
mouse ... Gap43(14432)
rat ... Gap43(29423)
Immunogen
synthetic phosphopeptide derived from the region of rat GAP-43 phosphorylated on serine 41.
Application
Anti-phospho-Growth Associated Protein-43 (pSer41) antibody produced in rabbit is suitable for immunoblotting at a working dilution of 1:1000.
Biochem/physiol Actions
GAP-43 is an intracellular phosphoprotein that is present exclusively in the peripheral and central nervous systems. Protein kinase C (PKC) phosphorylates GAP-43 on a single site, serine 41. This phosphorylated protein is found in the areas where growth cones make productive and stable contacts with other cells. It facilitates stabilization of long actin filaments. Phosphorylation by PKC at serine 41 is related to nerve-terminal sprouting and long-term potentiation as high levels of GAP-43 are present in neocortical areas and in the limbic system. It is crucial in mediating experience dependent plasticity.
Physical form
Solution in 10 mM HEPES, pH 7.5, containing 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol.
Analysis Note
An additional band at 150-160 kDa may be detected and reflects the oligomeric nature of GAP-43.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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H Rösner et al.
European journal of cell biology, 78(10), 698-706 (1999-11-24)
In spinal cord explant cultures from embryonic chicken (E7) we found that both a long-time downregulation of PKC by phorbol-12,13-dibutyrate (PDBu) and an inhibition of PKC by RO-31-8220 strongly reduce neurite outgrowth. Unlike this, in the presence of a high
Q He et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(10), 3515-3524 (1997-05-15)
Synthesis of GAP-43 (also known as neuromodulin) in neurons is induced during axon growth, and high concentrations (estimated between 50 and 100 microM) accumulate in the growth cone. GAP-43 is tightly associated with the growth cone membrane skeleton, the structure
L I Benowitz et al.
Trends in neurosciences, 20(2), 84-91 (1997-02-01)
Several lines of investigation have helped clarify the role of GAP-43 (FI, B-50 or neuromodulin) in regulating the growth state of axon terminals. In transgenic mice, overexpression of GAP-43 leads to the spontaneous formation of new synapses and enhanced sprouting
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