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G8041

Sigma-Aldrich

Galanin-Like Peptide Fragment 1-60 porcine trifluoroacetate salt

≥95% (HPLC), solid

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About This Item

Empirical Formula (Hill Notation):
C281H443N81O78
CAS Number:
245114-96-9
Molecular Weight:
6204.02
MDL number:
MFCD03456908
UNSPSC Code:
12352200
NACRES:
NA.32

assay

≥95% (HPLC)

form

solid

UniProt accession no.

Q9TT95

storage temp.

−20°C

Gene Information

pig ... GALP(396772)

Amino Acid Sequence

Ala-Pro-Val-His-Arg-Gly-Arg-Gly-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-His- Pro-Pro-Ser-Arg-Ala-Glu-Gly-Gly-Gly-Lys-Gly-Lys-Thr-Ala-Leu-Gly-Ile-Leu-Asp-Leu-Trp-Lys-Ala-Ile-Asp-Gly-Leu-Pro-Tyr-Pro-Gln-Ser-Gln-Leu-Ala-Ser

General description

Galanin-like peptide (GALP) is a GALR2 (galanin receptor)-binding neuropeptide, which is produced by pig hypothalamus. This peptide is produced as 120-residue GALP precursor protein, and is processed to a 60-residue peptide, with a non-amidated C-terminal.[1][2]

Biochem/physiol Actions

Endogenous ligand that preferentially binds to the GalR2 galanin receptor.
GALP-(1–60) peptide binds with high affinity to galanin receptor (GALR2).[1] This peptide is thought to play a role in mediating the actions of leptin, a satiety hormone.[2] It is a potent vasoactive peptide and is thought to be involved in inflammatory responses.[3]

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
016K1068
084K1793
045K1478
064K1358
091K1338

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Sabine M Schmidhuber et al.
The Journal of investigative dermatology, 127(3), 716-721 (2006-10-07)
The cutaneous vasculature plays a key role in the pathophysiology of inflammatory skin diseases. The vascular activity is under the control of the peripheral nervous system that includes locally released neuropeptides. Recently, we detected receptors for the neuropeptide galanin in
J A Larm et al.
Neuroendocrinology, 72(2), 67-71 (2000-09-06)
Galanin-like peptide (GALP) is a novel 60-amino acid neuropeptide, isolated from porcine hypothalamus and subsequently identified in rats and humans, which has reported selectivity for the Gal-R2 galanin receptor [Ohtaki T et al: J Biol Chem 1999; 274: 37041-37045]. In
T Ohtaki et al.
The Journal of biological chemistry, 274(52), 37041-37045 (1999-12-22)
Galanin is a widely distributed neuropeptide with a variety of physiological functions. Three galanin receptor subtypes, GALR1, GALR2, and GALR3, have been reported. We isolated a novel galanin-like peptide (GALP) from porcine hypothalamus by observing its activity for increasing [(35)S]GTPgammaS
Matthew J Cunningham et al.
Endocrinology, 143(3), 755-763 (2002-02-28)
Galanin-like peptide (GALP) is a newly discovered hypothalamic neuropeptide, which is regulated by leptin and implicated in the regulation of GnRH secretion in the rodent. We searched the human genome database and determined that the human GALP gene comprises six
Christina Springstead Scanlon et al.
Nature communications, 6, 6885-6885 (2015-04-29)
Perineural invasion (PNI) is an indicator of poor survival in multiple cancers. Unfortunately, there is no targeted treatment for PNI since the molecular mechanisms are largely unknown. PNI is an active process, suggesting that cancer cells communicate with nerves. However

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