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G7657

Sigma-Aldrich

Anti-GABA Transporter GAT-2 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

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About This Item

MDL number:
MFCD01633369
UNSPSC Code:
12352203

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

contains

0.02% sodium azide
1% bovine serum albumin

species reactivity

rat

technique(s)

immunohistochemistry: suitable

UniProt accession no.

P31646

shipped in

wet ice

storage temp.

−20°C

Gene Information

rat ... Slc6a13(171163)

Immunogen

synthetic peptide corresponding to the C-terminal domain (amino acids 594-602) of rat GAT-2.

Application

Anti-GABA Transporter GAT-2 antibody produced in rabbit is suitable for immunohistochemistry.

Biochem/physiol Actions

GAT-2 is a transporter for the selective uptake of γ-Aminobutyric acid (GABA). It belongs to a family of Na+ and Cl- co-dependent transporters, which include GAT-1, GAT-3 and BGT-1 transporters. These transporters have a molar mass of 67kDa each and contain 12 transmembrane regions. GABA is the major inhibitory neurotransmitter in the CNS and a neuromodulator in certain peripheral tissues.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
021K0233
120K0209

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B I Kanner
The Journal of experimental biology, 196, 237-249 (1994-11-01)
The removal of neurotransmitters by their transporters--located in the plasma membranes of nerve terminals and glial cells--plays an important role in the termination of synaptic transmission. In the last 3 years, many neurotransmitter transporters have been cloned. Structurally and functionally
L A Borden
Neurochemistry international, 29(4), 335-356 (1996-10-01)
gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. GABA is cleared from the synaptic cleft by specific, high-affinity, sodium- and chloride-dependent transporters, which are thought to be located on presynaptic terminals and surrounding glial cells. While
gamma-Aminobutyric acid outside the mammalian brain.
S L Erdö et al.
Journal of neurochemistry, 54(2), 363-372 (1990-02-01)

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