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Key Documents

G3894

Sigma-Aldrich

γ-D-Glutamylaminomethylsulfonic acid

Synonym(s):

GAMS

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About This Item

Empirical Formula (Hill Notation):
C6H12N2O6S
CAS Number:
Molecular Weight:
240.23
UNSPSC Code:
12352200
PubChem Substance ID:

form

solid

color

white

mp

216-218 °C

storage temp.

−20°C

SMILES string

OC([C@H](N)CCC(NCS(O)(=O)=O)=O)=O

InChI

1S/C6H12N2O6S/c7-4(6(10)11)1-2-5(9)8-3-15(12,13)14/h4H,1-3,7H2,(H,8,9)(H,10,11)(H,12,13,14)/t4-/m1/s1

InChI key

HCMBCMVOCRJSME-SCSAIBSYSA-N

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Biochem/physiol Actions

Gamma-D-Glutamylaminomethylsulfonic acid (GAMS) is used as a selective antagonist of AMPA/kainate glutamatergic receptors and as an anticonvulsant.
Selective antagonist at AMPA/kainate glutamatergic receptors; anticonvulsant.

Storage Class

13 - Non Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


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M Bamshad et al.
Brain research, 731(1-2), 213-216 (1996-08-26)
In Syrian hamsters, vasopressin (AVP) in the medial preoptic-anterior hypothalamus (MPOA-AH) controls a form of scent marking called flank marking. Another neurochemical signal that may interact with AVP to control flank marking is glutamate. We tested the hypothesis that glutamate
G De Sarro et al.
Brain research, 671(1), 131-140 (1995-02-06)
The behavioural and convulsant effects of imipenem (Imi), a carbapenem derivative, were studied after intraperitoneal (i.p.) or intracerebroventricular (i.c.v.) administration in DBA/2 mice, a strain genetically susceptible to sound-induced seizures. The anticonvulsant effects of some excitatory amino acid antagonists and
N Hata et al.
Neuroscience letters, 120(1), 101-104 (1990-11-27)
Bilateral infusion of DL-2-amino-5-phosphonovalerate (DL-APV) (which is a competitive antagonist for N-methyl-D-aspartate (NMDA) receptor) into the medial frontal cortex of conscious rats increased the amount of 3,4-dihydroxyphenylacetic acid (DOPAC) and the DOPAC/dopamine (DA) ratio in the cortical area. Moreover, intra-prefrontal
N L Tyurin
Bulletin of experimental biology and medicine, 148(2), 167-170 (2009-12-23)
We studied isolated pontobulbospinal preparations from newborn rat brain. In the early postnatal period, the rostral part of the medial vestibular nucleus produces a potent inhibitory effect on neuronal structures of the bulbar respiratory center via the glutamatergic system. Microinjection
N Zhou et al.
Hearing research, 60(1), 20-26 (1992-06-01)
Because kainic acid (KA) is more potent than other excitatory amino acids (EAAs) in affecting synaptic transmission in the cochlear nucleus, previous reports have concluded that primary afferent neurotransmission to the cochlear nucleus in birds and mammals is mediated by

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