All Photos(1)

Key Documents

COO/COA

View All Documentation

G1795

Anti-Glutamate Receptor 6, Metabotropic antibody produced in rabbit

Name: Anti-Glutamate Receptor 6, Metabotropic antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-mGluR6

Sign Into View Organizational & Contract Pricing

All Photos(1)

About This Item

MDL number:

MFCD03097014

UNSPSC Code:

12352203

NACRES:

NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human

availability

not available in Japan

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 12 μg/mL using human ganglion layer, retina

UniProt accession no.

O15303

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... GRM6(2916)
mouse ... Grm6(108072)
rat ... Grm6(24419)

Immunogen

synthetic peptide corresponding to the N-terminal extracellualr domain of human metabotropic glutamate receptor 6, conjugated to KLH. The immunizing peptide has 100% homology with the rat and mouse gene.

Application

Anti-Glutamate Receptor 6, Metabotropic antibody is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 12μg/mL using human ganglion layer, retina.

Biochem/physiol Actions

Glutamate, the excitatory neurotransmitter, is involved in fast excitatory synaptic transmission. It acts on ligand-gated receptor channels, termed NMDA, AMPA and kainate receptors. The metabotropic form consist of eight subtypes (mGluR1-8) divided into three groups (I-III). Group I binds to phospholipase C and intracellular calcium mobilization, whereas both groups II and III inhibit adenyl cyclase. The metabotropic receptors have some therapeutic potentials. group I receptors have been implicated in post-ischemic neuronal injury, and antagonists of group I appear to have a neuroprotective effect.

Physical form

Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.

Not finding the right product?

Try our Product Selector Tool.

Storage Class

10 - Combustible liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

The distinct role of mGlu1 receptors in post-ischemic neuronal death.

Domenico E Pellegrini-Giampietro

Trends in pharmacological sciences, 24(9), 461-470 (2003-09-12)

Metabotropic glutamate receptors of the mGlu(1) and mGlu(5) subtypes exhibit a high degree of sequence homology and are both coupled to phospholipase C and intracellular Ca(2+) mobilization. However, functional differences have been detected for these receptor subtypes when they are

Insight into the function of Group I and Group II metabotropic glutamate (mGlu) receptors: behavioural characterization and implications for the treatment of CNS disorders.

W Spooren et al.

Behavioural pharmacology, 14(4), 257-277 (2003-07-03)

Following the molecular cloning in the early 1990s of the metabotropic glutamate receptors (mGlu1-8), research that focused on the physiology, pharmacology and function of these receptors revealed their potential role in CNS disorders. Numerous psychiatric and neurological dis-orders are indeed

The metabotropic glutamate receptors: structure and functions.

J P Pin et al.

Neuropharmacology, 34(1), 1-26 (1995-01-01)

Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to

Neuroprotective activity of metabotropic glutamate receptor ligands.

Peter J Flor et al.

Advances in experimental medicine and biology, 513, 197-223 (2003-02-11)

Metabotropic glutamate receptors form a family of currently eight subtypes (mGluR1-8), subdivided into three groups (I-III). Activation of group-II (mGluR2 and -3) or group-III metabotropic glutamate receptors (mGluR4, -6, -7 and -8) has been established to be neuroprotective in vitro

Metabotropic glutamate receptors in the cerebellum with a focus on their function in Purkinje cells.

Thomas Knöpfel et al.

Cerebellum (London, England), 1(1), 19-26 (2003-07-26)

Metabotropic glutamate receptors (mGluRs) are a family of proteins that have seven transmembrane segments and that couple to G proteins. They differ from ionotropic glutamate receptors in that they do not form ion channels but instead affect intracellular chemical messenger

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service