G1674
Gliadorphin-7
Synonym(s):
α/β-Gliadin (43-49), GD-7, gluteomorphin, Prolamin (43-49)
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About This Item
UNSPSC Code:
12352200
biological source
wheat (gluten)
form
lyophilized powder
color
white
solubility
water, double-distilled: soluble
storage temp.
−20°C
Amino Acid Sequence
H-Tyr-Pro-Gln-Pro-Gln-Pro-Phe-OH
General description
Gliadorphin-7 is a peptide corresponding to amino-acids 43-49 of gliadin, a component of the gluten protein. Gliadorphin-7 is an opoid peptide formed in the body by the digestion of the gliadin. Accumulation of this peptide was found in autism, schizophrenia and cealic disease possibly due to improper proteolysis.
Gliadorphin-7 is one of the seven most commonly known gluten exorphins (GEs), which is a peptide derived from gliadin. Gliadin is a component of gluten found in wheat. Gliadorphin-7 peptide is produced upon the digestion of wheat glutens, and has an opioid-like activity. It is composed of Tyr-Pro-Gln-Pro-Gln-Pro-Phe, Gd-7.[1]
Biochem/physiol Actions
Gliadorphin-7 can reach regions in brain by diffusion circumventricular organs. Studies in rats show that gliadorphin-7 (GD-7) infusion results in high presence of this peptide in both geniculate nuclei (GN) and the alveus hippocampus.[2]
Physical form
Lyophilized from 0.1% aqueous TFA
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Release of wheat gluten exorphins A5 and C5 during in vitro gastrointestinal digestion of bread and pasta and their absorption through an in vitro model of intestinal epithelium.
Stuknyte, M et al
Food Research International, 72, 208-214 (2015)
Zhongjie Sun et al.
Peptides, 24(2), 321-323 (2003-04-02)
This paper discusses the effects of gliadorphin-7 (GD-7) infusion in rats and contrasts them with those of beta-casomorphin-7 (betaC-7). Both induce FLI in a dose related fashion. Very strong expression in both geniculate nuclei (GN) and the alveus hippocampus follow
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