G150
Granulocyte Chemotactic Protein-2 human
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
GCP-2
Sign Into View Organizational & Contract Pricing
All Photos(1)
About This Item
MDL number:
UNSPSC Code:
51111800
biological source
human
recombinant
expressed in E. coli
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
1.17 μg/mL
packaging
pkg of 25 μg
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... CXCL6(6372)
General description
GCP2 (granulocyte chemotactic protein 2) is a chemotactic chemokine and is expressed in mesenchymal cells and endothelial cells and fibroblasts showing angiogenic characteristics. It is a pro-inflammatory neutrophil chemoattractant. It is a member of the ELR+ (glutamic acid-leucine-arginine) CXC family, and shares the highest structural homology to IL-8 (interleukin 8).
Biochem/physiol Actions
GCP2 (granulocyte chemotactic protein 2) up-regulation in tumor cell allografts results in enhanced angiogenesis. It functions synergistically with MCP-1 (monocyte chemoattractant protein) chemokines to induce neutrophil mobilization and tumor angiogenesis. This protein is present in amniotic fluid, and this concentration decreases with advancing stages of gestation. Thus, it is thought to confer immune protection against invading microbes in the amniotic cavity. In diseased gingival tissues, it works in orchestration with IL-8 (interleukin 8), which is linked to the severity of periodontal disease. This protein is also involved in antibacterial activity during localized infection.
Physical form
Lyophilized from a 0.2 μm filtered solution of 30% acetonitrile and 0.1% trifluoroacetic acid containing 1.25 mg bovine serum albumin
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
R P Johnson et al.
The Journal of biological chemistry, 275(1), 95-105 (2000-01-05)
The tail domain of vinculin (V(t)) is an actin binding module containing two regions that interact with F-actin. Although intact V(t) purified from a bacterial expression system is a globular monomer, each actin binding region dimerizes when expressed individually, suggesting
Bulei Wang et al.
Carbohydrate polymers, 246, 116620-116620 (2020-08-05)
In this study, a water-soluble polysaccharide (BSP) was extracted and purified from pseudobulb of Bletilla striata. The preliminary structure and gastroprotective activity of BSP were analyzed. Results indicate that BSP is a glucomannan with a molar ratio of 7.45:2.55 (Man:Glc)
Vladimir A Ledov et al.
Vaccine, 37(8), 1062-1072 (2019-01-24)
Shigellosis, a major cause of diarrhea worldwide, exhibits high morbidity and mortality in children. Specificity of Shigella immunity is determined by the structure of the main protective O-antigen polysaccharide component incorporated into the lipopolysaccharide (LPS) molecule. Endotoxicity, however, precludes LPS
Sung-Whan Kim et al.
Cardiovascular research, 95(4), 495-506 (2012-08-14)
In this study, our aim was to evaluate the angio-vasculogenic properties of human adipose tissue-derived mesenchymal stem cells overexpressing the granulocyte chemotactic protein (GCP)-2 (hASCs/GCP-2) and to determine possible therapeutic effects in an experimental ischaemic heart model. Quantitative real-time (qRT)-PCR
Himanshu Mishra et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 13(4), 495-509 (2010-01-01)
Solid lipid nanoparticles (SLN) have emerged as carriers for therapeutic peptides, proteins, antigens and bioactive molecules. We have explored the potential of SLN as carrier for Hepatitis B surface antigen (HBsAg) by surface modifications to enhance their loading efficiency and
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service