G Protein-Coupled Receptor belongs to the largest known receptor family. It is characterized by seven transmembrane domains with an extracellular N terminus and a cytoplasmic C terminus domain. They are further divided into distinct subfamilies depending on their different types of ligands and according to sequence homologies. It is highly expressed in liver, kidney, peripheral leukocyte, lung, and spleen, than in other tissues.
Immunogen
synthetic peptide corresponding to the C-terminus of human G-protein-coupled receptor TG1019, conjugated to KLH.
Application
Anti-G Protein-Coupled Receptor TG1019 antibody is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 30μg/mL using liver.
Biochem/physiol Actions
G Protein-Coupled Receptor has the ability to alter variety of extracellular signals such as photons, odorants, biogenic amines, peptides, hormone proteins, proteases, nucleotides, and lipids.
Using a bioinformatics approach, we have isolated a novel G-protein-coupled receptor (GPCR), R527, and have demonstrated that this receptor shows no significant homology to previously deorphanized GPCRs. Quantitative reverse transcription-polymerase chain reaction analysis of the expression of GPCR R527 indicated
The Journal of biological chemistry, 277(35), 31459-31465 (2002-06-18)
We have conducted an in silico data base search for and cloned a novel G-protein-coupled receptor (GPCR) named TG1019. Dot and Northern blotting analyses showed that transcripts of the novel GPCR were expressed in various tissues except brain, and the
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