synthetic peptide corresponding to the C-terminal domain of human galanin receptor 3, conjugated KLH. The immunizing peptide has 100% homology with the rat and mouse gene.
Application
Anti-Galanin Receptor 3 antibody is suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 4μg/mL using human brain, neurons and glia.
Biochem/physiol Actions
Galanin, a small amino acid peptide, is widely expressed in human testis and also in adrenal gland and pancreas to lesser extent. It exerts a broad range of physiological effects. Galanin Receptor 3 is associated with various processes such as hormone release, feeding behavior, smooth muscle contractility and somatosensory neuronal function. Three distinct galanin receptor (GALR) subtypes, designated GALR1, 2, and 3, have been found.
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Annals of the New York Academy of Sciences, 863, 56-63 (1999-02-03)
Human galanin receptor subtypes GALR1, GALR2, and GALR3 are encoded by separate genes that are located on human chromosomes 18q23, 17q25.3, and 22q13.1, respectively. The exon:intron organization of the gene encoding GALR2 (GALNR2) and GALR3 (GALNR3) is conserved, with exon
The Journal of biological chemistry, 273(36), 23321-23326 (1998-08-29)
The neuropeptide galanin has been implicated in the regulation of processes such as nociception, cognition, feeding behavior, and hormone secretion. Multiple galanin receptors are predicted to mediate its effects, but only two functionally coupled receptors have been reported. We now
Trends in pharmacological sciences, 21(3), 109-117 (2000-02-26)
The neuropeptide galanin, which is widely expressed in brain and peripheral tissues, exerts a broad range of physiological effects. Pharmacological studies using peptide analogues have led to speculation about multiple galanin receptor subtypes. Since 1994, a total of three G-protein-coupled
Journal of neurochemistry, 71(6), 2239-2251 (1998-12-01)
Galanin is a 29- or 30-amino acid peptide with wide-ranging effects on hormone release, feeding behavior, smooth muscle contractility, and somatosensory neuronal function. Three distinct galanin receptor (GALR) subtypes, designated GALR1, 2, and 3, have been cloned from the rat.
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