G0420

Anti-Glycine Receptor α3 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

• MDL number: MFCD02686167
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: lyophilized powder
• species reactivity: rat, human, mouse
• technique(s): western blot: 1:200 using rat brain membranes
• UniProt accession no.: O75311
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... GLRA3(8001) ; mouse ... Glra3(110304) ; rat ... Glra2(24397)

Description

General description

Glycine receptors are group I ligand-gated ion channel (LGICs) proteins that belong to the Cys loop receptor family. It has been reported that there are three polypeptide species: GlyR (48kDa) and GlyR (58kDa) subunits and a tightly bound cytosolic scaffolding protein (93kDa) later named gephyrin. It appears to exist as a heteropentameric proteins with an oligomeric transmembrane protein made up of three α and two β subunits. It has been identified that glycine receptors contains four subunit isoforms (α1-α4) and a single β subunit forming GlyR. It helps in mediating synaptic inhibition in the spinal cord, retina and brain of vertebrates.

Specificity

Rat, mouse, and human sequences are identical.

Immunogen

synthetic peptide corresponding to residues 355-368 of rat glycine receptor α3.

Application

Anti-Glycine Receptor α3 antibody is suitable for western blot at a dilution of 1:200 using rat brain membranes.

Target description

Glycine Receptor α3 encodes the α3 subunit of the neuronal glycine receptor, a ligand-gated chloride channel composed of ligand-binding α and structural β polypeptides.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, 1% BSA, and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable