F9176
Anti-phospho-FAK (pTyr861) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-phospho-Focal Adhesion Kinase
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
species reactivity
frog, chicken, human, mouse
technique(s)
immunohistochemistry: suitable
western blot: 1:1,000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr861)
Gene Information
human ... PTK2(5747)
mouse ... Ptk2(14083)
General description
Focal adhesion kinase (FAK) is a cytoplasmic protein that belongs to non-receptor protein tyrosine kinase family. It has a critical role in regulation of cell differentiation, migration, adhesion and acceleration of the G1 to S phase transition in cell cycle. Anti-phospho-FAK (pTyr861) antibody can be used in immunohistochemistry. Rabbit anti-phospho-FAK (pTyr861) antibody reacts specifically with FAK (125kD) phosphorylated at tyrosine 861. This product can also react with FAK (pTyr861) of mouse, chicken and human.
Focal adhesion kinase (FAK) is a non-receptor cytoplasmic protein tyrosine kinase. It is coded by the PTK2 (protein tyrosine kinase 2) gene that is located on human chromosome 8q24.3.
Immunogen
synthetic phosphopeptide derived from the region of FAK that contains tyrosine 861.
Application
Anti-phospho-FAK (pTyr861) antibody can be used in western blotting (diluted 1:1000).
Biochem/physiol Actions
Focal adhesion kinase (FAK) participates in cell signaling pathways that leads to cell proliferation, invasion, survival and metastasis. It is essential for normal embryonic development. This protein controls CSC (cancer stem cells) properties in breast, gastrointestinal and squamous cell carcinoma.
Physical form
Solution in Dulbecco′s phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, with 50% glycerol, 1.0 mg/ml BSA (IgG and protease free) and 0.05% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Chifumi Ohyagi-Hara et al.
The American journal of pathology, 182(5), 1876-1889 (2013-03-19)
Ovarian cancer is characterized by widespread peritoneal dissemination and ascites and has a cure rate of only 30%. As has been previously reported, integrin α5 plays a key role in the peritoneal dissemination of ovarian cancer. Our aim was to
J D Owen et al.
Molecular and cellular biology, 19(7), 4806-4818 (1999-06-22)
Focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase involved in integrin-mediated control of cell behavior. Following cell adhesion to components of the extracellular matrix, FAK becomes phosphorylated at multiple sites, including tyrosines 397, 576, and 577. Tyr-397 is
Hua-Li Yu et al.
International journal of molecular sciences, 25(13) (2024-07-13)
Microglia migrate to the cerebral cortex during early embryonic stages. However, the precise mechanisms underlying microglia migration remain incompletely understood. As an extracellular matrix protein, Netrin-1 is involved in modulating the motility of diverse cells. In this paper, we found
Potential roles for focal adhesion kinase in development.
Ridyard MS, Sanders EJ
Anat. Embryol., 199(1), 1-7 (1999)
Adrian Krajewski et al.
Cancer management and research, 12, 13085-13097 (2020-12-31)
Cyclins are well-known cell cycle regulators. The activation of cyclin-dependent kinases by cyclins allows orchestration of the complicated cell cycle machinery and drives the cell from the G1 phase to the end of the mitotic phase. In recent years, it
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