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F8927

Flupirtine maleate salt

≥98% (HPLC)

Synonym(s):

2-Amino-6-[[(4-fluorophenyl)methyl]amino]-3-pyridinyl]-carbamic acid ethyl ester maleate salt

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5 mg

Estimated to ship onMarch 23, 2026fromMILWAUKEE

$145.00
25 mg

Estimated to ship onMarch 23, 2026fromMILWAUKEE

$495.00

About This Item

Empirical Formula (Hill Notation):
C15H17FN4O2 · C4H4O4
CAS Number:
75507-68-5
Molecular Weight:
420.39
NACRES:
NA.77
PubChem Substance ID:
24278445
UNSPSC Code:
12352200
MDL number:
MFCD00941415
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100

$145.00

Estimated to ship onMarch 23, 2026Details

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Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: soluble >20 mg/mL, H2O: insoluble

storage temp.

2-8°C

SMILES string

OC(=O)\C=C/C(O)=O.CCOC(=O)Nc1ccc(NCc2ccc(F)cc2)nc1N

InChI

1S/C15H17FN4O2.C4H4O4/c1-2-22-15(21)19-12-7-8-13(20-14(12)17)18-9-10-3-5-11(16)6-4-10;5-3(6)1-2-4(7)8/h3-8H,2,9H2,1H3,(H,19,21)(H3,17,18,20);1-2H,(H,5,6)(H,7,8)/b;2-1-

InChI key

DPYIXBFZUMCMJM-BTJKTKAUSA-N

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Flupirtine maleate salt ≥98% (HPLC)

Sigma-Aldrich

F8927

Flupirtine maleate salt

Paroxetine maleate salt ≥98% (HPLC), solid

Sigma-Aldrich

P1372

Paroxetine maleate salt

UM-164 trifluoroacetate salt ≥98% (HPLC)

Sigma-Aldrich

SML1928

UM-164 trifluoroacetate salt

Ferrostatin-1 ≥95% (HPLC)

Sigma-Aldrich

SML0583

Ferrostatin-1

form

solid

form

solid

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: soluble >20 mg/mL, H2O: insoluble

solubility

DMSO: ~12 mg/mL, H2O: insoluble

solubility

H2O: 10 mg/mL, clear

solubility

DMSO: 10 mg/mL, clear

color

white

color

white to off-white

color

white to beige

color

, faint purple to brown

Biochem/physiol Actions

Non-opioid analgesic; cytoprotective versus PrP fragment 106-126
Flupirtine is commercially available as maleate salt. It exists in two polymorphs : flupirtine maleate A and B. Flupirtine is useful in treating muscular spasm, muscle tension and muscle stiffness. It is known to be effective in relieving back pain. Along with cytoprotection, flupirtine also offers protection against neurodegenerative disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer′s disease, Parkinson′s disease, Huntington′s chorea and AID (acquired immunodeficiency) associated encephalopathy. Flupirtine is found to be a potential drug for eye-related problems like maculopathy including diabetic retinopathy, retinitis pigmentosa and glaucoma. It is also proved to be helpful in preventing cardiac associated disorders such as myocardial ischemia and infarction, cerebral ischemia and infarction. Hepatitis is also prevented by the use of flupirtine.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000507068
0000507067
0000507067
0000507068
0000423902

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Felicia Klinger et al.
British journal of pharmacology, 166(5), 1631-1642 (2011-12-23)
Flupirtine is a non-opioid analgesic that has been in clinical use for more than 20 years. It is characterized as a selective neuronal potassium channel opener (SNEPCO). Nevertheless, its mechanisms of action remain controversial and are the purpose of this
Anton Kolosov et al.
Pain medicine (Malden, Mass.), 13(11), 1444-1456 (2012-10-20)
Current treatments for cancer pain are often inadequate, particularly when metastasis to bone is involved. The addition to the treatment regimen of another drug that has a complementary analgesic effect may increase the overall analgesia without the necessity to increase
Martin C Michel et al.
British journal of clinical pharmacology, 73(5), 821-825 (2011-11-03)
To determine efficacy of the analgesic flupirtine in the treatment of overactive bladder syndrome in a proof-of-concept study. Double-blind, double-dummy, three-armed comparison of flupirtine extended release (400 mg/day, titrated to 600 mg/day), tolterodine extended release (4 mg/day) and placebo for
Fang Yu et al.
Epilepsy research, 97(1-2), 64-72 (2011-08-13)
Activation of KCNQ-channels has been shown to decrease or reduce the propagation of neuronal excitation in the immature central nervous system, and KCNQ activators represent a new class of anticonvulsant compounds. Their effectiveness has been demonstrated in many seizure models
Syed Mohammed Naser et al.
Journal of the Indian Medical Association, 110(3), 158-160 (2012-10-04)
The study was conducted to evaluate the efficacy and safety of flupirtine maleate 100 mg thrice daily compared to tramadol hydrochloride 50 mg thrice daily as postoperative pain management for 5 days. A total of 113 postoperative patients were recruited
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Related Content

Data Sheet - F8927

Instructions

Global Trade Item Number

SKUGTIN
F8927-25MG04061833621202
F8927-5MG04061833621226

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