F8557

FK866 hydrochloride hydrate

≥98% (HPLC), powder, NAD biosynthesis inhibitor

• Synonym(s): FK866 hydrochloride hydrate, (E)-N-[4-(1-benzoylpiperidin-4-yl)butyl]-3-(pyridin-3-yl)acrylamide, K22.175
• Empirical Formula (Hill Notation): C₂₄H₂₉N₃O₂·HCl · xH₂O
• CAS Number: 658084-64-1
• Molecular Weight: 427.97 (anhydrous basis)
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• product name: FK866 hydrochloride hydrate, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• storage condition: desiccated
• color: white to beige
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: −20°C
• InChI: 1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
• InChI key: KPBNHDGDUADAGP-VAWYXSNFSA-N

Description

General description

FK866 is used to treat inflammatory diseases and cancer.

Application

FK866 hydrochloride hydrate has been used:

• to investigate its effects on intra-axonal NAD⁺ levels
• to induce NAD+ depletion
• to reduce the level of tumor necrosis factor-α (TNF-α), nicotinamide phosphoribosyltransferase (NAMPT) and interleukin-6 (IL-6) in the ischemic brain tissue

Biochem/physiol Actions

FK866 is a potent inhibitor of NAD biosynthesis, and a specific inhibitor of NAMPT (Nicotinamide Phosphoribosyltransferase, visfatin, PBEF). NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAMPT also acts as a cytokine independent of its enzymatic activity, playing a major part in regulating immune responses.

Safety Information

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable