F6931

Anti-FGL1 (281-295) antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

• Synonym(s): Anti-FGL1 fibrinogen-like 1, Anti-HFREP1, Anti-HP-041, Anti-LFIRE1
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: IgG fraction of antiserum
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~34 kDa
• species reactivity: human
• technique(s): western blot: 1:500-1:2,000
• UniProt accession no.: Q08830
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... FGL1(2267)

Description

Immunogen

synthetic peptide corresponding to amino acids 281-295 of human FGL1

Application

Anti-FGL1 (281-295) antibody is suitable for western blot at a dilution of 1:500-1:2,000.
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if.

Biochem/physiol Actions

FGL1 belongs to the fibrinogen family, the principal protein in formation of blood clots in vertebrates. It exists as a multimeric protein structure comprising two copies of three homologous polypeptide chains (α2, β2, γ2). It is reacted with the thrombin-like enzyme, forming a fibrin-like substance in blood coaggulation. The downregulation of the protein is significantly associated with the differentiation of hepatocellular carcinomas (HCC). It has been reported that in deregulation of FGL1, it acts in cell growth and tumorigenicity in vitro and in vivo. Studies conclude that FGL1 may contribute in hepatocarcinogenesis.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)