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F6506

Sigma-Aldrich

Anti-Human Polyvalent Immunoglobulins (G,A,M)–FITC antibody produced in goat

IgG fraction of antiserum, buffered aqueous solution

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About This Item

MDL number:
UNSPSC Code:
12352203

biological source

goat

Quality Level

conjugate

FITC conjugate

antibody form

IgG fraction of antiserum

antibody product type

secondary antibodies

clone

polyclonal

form

buffered aqueous solution

technique(s)

direct immunofluorescence: 1:128

Storage temp.

2-8°C

target post-translational modification

unmodified

General description

IgG antibody subtype is the most abundant serum immunoglobulins of the immune system. It is secreted by B cells and is found in blood and extracellular fluids and provides protection from infections caused by bacteria, fungi and viruses. Maternal IgG is transferred to fetus through the placenta that is vital for immune defence of the neonate against infections. IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears and saliva. IgM antibodies are present as pentamers in the serum and are produced in response to antigens
Purified human IgA, IgG and IgM are used to develop anti-sera in goats. The IgG fraction of each anti-sera is purified and conjugated to Fluorescein Isothiocyanate (FITC), Isomer I. Anti-Human Polyvalent Immunoglobulins (G,A,M)-FITC antibody specifically recognizes human IgA, IgG and IgM.

Immunogen

Purified human IgA, IgG, and IgM

Application

Anti-Human Polyvalent Immunoglobulins (G,A,M)-FITC antibodies may be used for direct immunofluorescence (1:128).
Anti-Human Polyvalent Immunoglobulins (G,A,M)–FITC antibody may be used for immunofluorescence of human peripheral blood lymphocytes at a working antibody dilution of 1:128. This antibody was used to stain dried erythrocytes infected with Plasmodium falciparum at a dilution of 1:60. For flow cytometry analysis of intra-uterine stages of filarial worms, a dilution of 1:250 was used. For immunohistochemical analysis of formalin-fixed, paraffin-embedded rhesus monkey eye sections, a dilution of 1:200 was used.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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Giuseppe Querques et al.
Acta ophthalmologica, 88(5), 571-575 (2009-01-15)
To report an unusual association between cancer-associated retinopathy (CAR) associated with invasive thymoma and choriodal neovascularization (CNV), treated by photodynamic therapy (PDT). A 39-year-old man affected with thymoma and paraneoplastic syndrome (myasthenia gravis and diarrhoea) was observed between October 1997
E Schwartz et al.
Journal of travel medicine, 8(3), 113-116 (2001-07-27)
The United Nations deployed about 8,000 soldiers in a peacekeeping mission in Angola. Malaria is the most common disease there and consequently it was the major risk to the UN troops. Most of them are from malaria free areas. As
Bikash Ranjan Sahu et al.
Filaria journal, 4(1), 11-11 (2005-11-09)
In the absence of intermediate animal hosts, the process of embryogenesis leading to fecundity of adult female filarial worms is very critical for persistence of these obligate parasites in human communities. Embryogenesis in adult female filarial parasites involves fertilization of
Micha Rosenkranz et al.
NPJ vaccines, 8(1), 112-112 (2023-08-10)
Radical control of malaria likely requires a vaccine that targets both the asymptomatic liver stages and the disease-causing blood stages of the human malaria parasite Plasmodium falciparum. While substantial progress has been made towards liver stage vaccines, the development of
Siril S Bakke et al.
Journal of immunology (Baltimore, Md. : 1950), 199(8), 2910-2920 (2017-09-01)
Cholesterol crystals (CC) are abundant in atherosclerotic plaques and promote inflammatory responses via the complement system and inflammasome activation. Cyclic oligosaccharide 2-hydroxypropyl-β-cyclodextrin (BCD) is a compound that solubilizes lipophilic substances. Recently we have shown that BCD has an anti-inflammatory effect

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