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F5900

Sigma-Aldrich

Monoclonal Anti-Interleukin-2−Carboxyfluorescein antibody produced in mouse

clone 5334, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Monoclonal Anti-Interleukin-2, Monoclonal Anti-IL-2

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.41

biological source

mouse

Quality Level

conjugate

carboxyfluorescein conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

5334, monoclonal

form

buffered aqueous solution

species reactivity

human

technique(s)

flow cytometry: suitable

isotype

IgG1

UniProt accession no.

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... IL2(3558)

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General description

Interleukin-2 (IL-2) also refers as T Cell Growth Factor is a cytokine produced by certain subsets of T lymphocytes. It plays various functions like inducing interferon γ and B cell growth factor secretion as well as affecting the activation and proliferation of NK cells. It also has a vital role in modulating the expression of the IL-2 receptor and can facilitate B cell growth and differentiation. Monoclonal anti-Interleukin-2−Carboxyfluorescein antibody reacts specifically with human IL-2.

Specificity

The conjugates will identify and quantitate cells containing intracellular forms of human IL-2 by flow cytometry.

Immunogen

recombinant human IL-2

Application

Monoclonal anti-Interleukin-2−Carboxyfluorescein antibody can be used in flow cytometry assays for identifying intracytoplasmic cytokines and for enumerating cytokine producing cells present in a mixed population.

Physical form

Solution in phosphate buffered saline containing 0.1% sodium azide.

Preparation Note

Purified antibody is conjugated to carboxyfluorescein.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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D A Morgan et al.
Science (New York, N.Y.), 193(4257), 1007-1008 (1976-09-10)
Selective growth of T lymphocytes occurred when unfractionated normal human bone marrow cells were cultured with conditioned medium obtained from phytohemagglutinin-stimulated normal human lymphocytes (Ly-CM). Cultures of up to 90 percent T cells have been maintained for more than 9
T A Waldmann et al.
The Journal of experimental medicine, 160(5), 1450-1466 (1984-11-01)
Using anti-Tac, a monoclonal anti-interleukin 2 (IL-2) receptor antibody, we have explored the possibility that certain activated B cells display receptors for IL-2. Resting normal B cells and unselected B cell lines established from normal individuals were Tac antigen negative.
K A Smith et al.
Proceedings of the National Academy of Sciences of the United States of America, 82(3), 864-868 (1985-02-01)
The cell surface density of high-affinity membrane receptors for the T-lymphocytotrophic hormone interleukin 2 (IL-2) determines the rate of T-cell-cycle progression. Since 10-fold greater numbers of IL-2 receptor molecules were found by using a radiolabeled monoclonal antibody reactive with IL-2

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