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Key Documents

F5398

Sigma-Aldrich

FK-Binding Protein human

recombinant, expressed in E. coli

Synonym(s):

FKBP-12

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352202

recombinant

expressed in E. coli

UniProt accession no.

storage temp.

2-8°C

Gene Information

human ... FKBP1A(2280)

General description

Recombinant FK-binding protein, characterized by binding to, and inhibition by, the immunosuppressant, FK-506.1.[1]

Biochem/physiol Actions

Enzyme which catalyzes cis-trans isomerization of X-Pro peptide bonds (i.e., a peptidyl prolyl isomerase) in synthetic substrates.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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G Fischer et al.
Biomedica biochimica acta, 43(10), 1101-1111 (1984-01-01)
The rates of cis to trans interconversion of Glt-(Ala)n-Pro-Phe-4-nitroanilides (n = 1-3) were estimated by means of a two-step process with chymotrypsin as the trans-substrate cleaving activity. By the aid of this system, pig kidney and several other tissues contained
R E Handschumacher et al.
Science (New York, N.Y.), 226(4674), 544-547 (1984-11-02)
Cyclophilin, a specific cytosolic binding protein responsible for the concentration of the immunosuppressant cyclosporin A by lymphoid cells, was purified to homogeneity from bovine thymocytes. Cation-exchange high-performance liquid chromatography resolved a major and minor cyclophilin species that bind cyclosporin A

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