F4930
FES, active, GST tagged human
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Synonym(s):
FPS
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About This Item
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
48-64 nmol/min·mg
mol wt
~125 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... FES(2242)
General description
FES is a protein-tyrosine kinase, which was first identified as a homolog of transforming oncogene in avian and feline retrovirus. It is a 93kDa protein, which is expressed in endothelial, epithelial, myeloid, vascular and neuronal cells.[1]
Biochem/physiol Actions
FES regulates the growth and differentiation of neurons, hematopoietic, vascular endothelial and epithelial cell lines. Inactivation of this gene leads to suppression of human renal carcinoma cell proliferation, and thus, might have potential as a therapeutic target.[2] It is a highly regulated oncogene, and in transgenic mice, its up-regulation leads to tissue hyperplasia, hemangioma formation and oncogenic transformation of fibroblasts. It however, acts as a tumor suppressor in colorectal cancer (CRC), where it is inactivated due to promoter methylation.[1]
Physical form
Supplied in 50 mM Tris-HCl, pH 7.5, with 150 mM NaCl, 0.2 5mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, and 25% glycerol.
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Shigeru Kanda et al.
International journal of oncology, 34(1), 89-96 (2008-12-17)
The c-Fes protein-tyrosine kinase is associated with growth and differentiation of hematopoietic, neuronal, vascular endothelial and epithelial cell types. In this study, we investigated whether small interfering RNA (siRNA)-mediated knockdown of c-Fes expression affected proliferation of the human renal carcinoma
Peter Greer
Nature reviews. Molecular cell biology, 3(4), 278-289 (2002-05-08)
Fps/Fes and Fer are the only known members of a distinct subfamily of the non-receptor protein-tyrosine kinase family. Recent studies indicate that these kinases have roles in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix
T E Smithgall et al.
Critical reviews in oncogenesis, 9(1), 43-62 (1998-10-01)
The human c-fes protooncogene encodes a protein-tyrosine kinase (c-Fes) distinct from c-Src, c-Abl and other nonreceptor tyrosine kinases. Although originally identified as the cellular homolog of several transforming retroviral oncoproteins, Fes was later found to exhibit strong expression in myeloid
Jonathan M Shaffer et al.
Genes, chromosomes & cancer, 48(3), 272-284 (2008-12-04)
The FES locus encodes a unique nonreceptor protein-tyrosine kinase (FES) traditionally viewed as a proto-oncogene but more recently implicated as a tumor suppressor in colorectal cancer (CRC). Recent studies have demonstrated that while FES is expressed in normal colonic epithelium
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