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F3901

Sigma-Aldrich

Monoclonal Anti-Interleukin-4−Carboxyfluorescein antibody produced in mouse

clone 3007.11, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Monoclonal Anti-Interleukin-4, Anti-IL-4

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About This Item

UNSPSC Code:
51111800
NACRES:
NA.41

biological source

mouse

conjugate

carboxyfluorescein conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

3007.11, monoclonal

form

buffered aqueous solution

species reactivity

human

storage condition

protect from light

technique(s)

flow cytometry: suitable

isotype

IgG1

UniProt accession no.

P05112

shipped in

wet ice

Storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... IL4(3565)

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Specificity

The conjugates will identify and quantitate cells containing intracellular forms of human IL-4.

Immunogen

recombinant human IL-4

Biochem/physiol Actions

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The signaling stimulated by IL-4 by binding to its receptors leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. IL-4 mediates endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. The coupling of Carboxyfluorescein to Anti-Interleukin-4 antibody allows for flow cytometry applications.

Physical form

Solution in saline containing up to 0.5% bovine serum albumin and up to 0.1% of sodium azide as a preservative.

Preparation Note

Purified antibody is conjugated to carboxyfluorescein (FITC).

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
081M1475
049K1258
075K1876
073K0577
069H0077

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Jane Gilmour et al.
Immunology, 124(4), 437-444 (2008-05-16)
The mechanism of differentiation of naïve T cells to a variety of effector lineages, but particularly to T helper type 1 (Th1) and Th2 cells, has been the subject of intense scrutiny over the past two decades. Studies have revealed
Hao-Wei Wang et al.
Cell cycle (Georgetown, Tex.), 9(24), 4824-4835 (2010-12-15)
Although macrophages were originally recognized as major immune effector cells, it is now appreciated that they also play many important roles in the maintenance of tissue homeostasis, and are involved in a variety of pathological conditions including cancer. Several studies
H Jiang et al.
The Journal of allergy and clinical immunology, 105(6 Pt 1), 1063-1070 (2000-06-16)
In the past several years, extensive studies on the mechanisms underlying IL-4 and IL-13 signaling have enabled us to gain insight into how these cytokines regulate immune responses. Because both IL-4 and IL-13 use the IL-4Ralpha as a receptor component

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