F3803
Monoclonal Anti-Follicular Dendritic Cells (FDC) antibody produced in mouse
clone CNA.42, tissue culture supernatant
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
tissue culture supernatant
antibody product type
primary antibodies
clone
CNA.42, monoclonal
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:50 using human tonsil
immunohistochemistry (frozen sections): 1:25-1:50 using acetone-fixed, cryostat sections of human tonsil
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Immunogen
mouse CEM T cell line.
Application
Monoclonal Anti-Follicular Dendritic Cells (FDC) antibody is suitable for immunohistochemistry studies of formalin-fixed, paraffin-embedded sections at a dilution of 1:25-1:50 using human tonsil and frozen sections at a dilution of 1:25-1:50 using acetone-fixed, cryostat sections of human tonsil.
Biochem/physiol Actions
Follicular dendritic cells (FDCs) are phenotypically distinct cells that are restricted to primary and secondary follicles of any secondary lymphoid organs, lymphoid dendritic cells are found in T cell-rich interfollicular areas. FDCs are morphologically large cells (often containing multiple nuclei) that exhibit numerous dendritic processes. Initially, FDCs are characterized as ′accessory′ cells that passively support germinal centre (GC) responses. However, latter it has been postulated that FDCs actively shape humoral immunity.
Physical form
Tissue culture supernatant (culture medium with fetal calf serum), containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Balthasar A Heesters et al.
Nature reviews. Immunology, 14(7), 495-504 (2014-06-21)
Follicular dendritic cells (FDCs) are essential for high-affinity antibody production and for the development of B cell memory. Historically, FDCs have been characterized as 'accessory' cells that passively support germinal centre (GC) responses. However, recent observations suggest that FDCs actively
S Petrasch et al.
British journal of haematology, 80(1), 21-26 (1992-01-01)
Follicular dendritic cells (FDC) are located within the B-cell follicles of non-malignant lymphatic tissues and within non-Hodgkin-lymphomas (NHL) derived from the germinal centre or the mantlezone. The interactions between FDC and non-neoplastic B-cells have been extensively investigated but so far
Kirsten van Nierop et al.
Seminars in immunology, 14(4), 251-257 (2002-08-07)
Follicular dendritic cells (FDCs) have important functions in the selection of memory B lymphocytes during germinal center reactions (GCR). They present native antigens to potential memory cells, of which only B cells with high affinity B cell receptors (BCR) can
Lili Wang et al.
Human gene therapy, 22(11), 1389-1401 (2011-04-12)
Vectors based on the primate-derived adeno-associated virus serotype 8 (AAV8) are being evaluated in preclinical and clinical models. Natural infections with related AAVs activate memory B cells that produce antibodies capable of modulating the efficacy and safety of the vector.
Eirini Moysi et al.
Frontiers in immunology, 12, 683396-683396 (2021-06-29)
CD4 T cells are key mediators of adaptive immune responses during infection and vaccination. Within secondary lymphoid organs, helper CD4 T cells, particularly those residing in germinal centers known as follicular helper T cells (Tfh), provide critical help to B-cells
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