F3304
Anti-Frizzled-2 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-FZD2
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About This Item
MDL number:
UNSPSC Code:
12352203
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
availability
not available in Japan
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 7.6 μg/mL using human kidney, fetal
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... FZD2(2535)
mouse ... Fzd2(57265)
rat ... Fzd2(64512)
Immunogen
synthetic peptide corresponding to the third extracellular loop of human frizzled-2, conjugated to KLH. The immunizing peptide has 100% homology with rat and mouse gene.
Application
Anti-Frizzled-2 antibody is suitable for western blotting and immunofluorescence labelling to study the expression of Wnt5a and its receptor Fzd2 in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice. It is also suitable for immunohistochemistry studies formalin-fixed, paraffin-embedded sections in concentration of ~7.6μg/mL, using human kidney, fetal.
Biochem/physiol Actions
Frizzled-2 belongs to frizzled (FZD) family. Frizzled homolog protein (FZD) is a seven-pass transmembrane type receptor expressed in various normal tissues (skeletal muscle, kidney, pancreas, cerebellum and cerebral cortex). In human, ten members (FZD1-FZD10) of Frizzled homolog protein have been identified. Generally, it is expressed in most human adult and fetal tissues, but it is found to be over expressed in several cancers such as primary Wilms′ tumour, melanoma and lung squamous cell carcinoma. FZD2 is directly associated with Wnt signaling pathway. It binds to Wnt5a to activate the WNT/Ca2+signaling pathway in melanoma cell lines and also in presence of Wnt3a, can facilitate Wnt/β-catenin signaling in pulmonary carcinoma.
Physical form
Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide.
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Xiaojin Li et al.
International journal of clinical and experimental pathology, 6(7), 1245-1260 (2013-07-05)
Wnt5a, a member of the Wnt gene family, encodes a cysteine-rich growth factor involved in signal transduction during growth and differentiation. The Fzd2 gene codes for a cell membrane receptor called Frizzled-2 have a structure similar to G protein coupled
Ettore Salsano et al.
Journal of neuro-oncology, 106(2), 271-280 (2011-08-19)
Secreted WNT proteins signal through ten receptors of the frizzled (FZD) family. Because of the relevance of the WNT/β-catenin (CTNNB1) signaling pathway in medulloblastomas (MBs), we investigated the expression of all ten members of the FZD gene family (FZD1-10) in
H Kirikoshi et al.
International journal of oncology, 19(4), 767-771 (2001-09-20)
Frizzled (FZD) genes encode seven-transmembrane type WNT receptors, which are implicated in carcinogenesis and embryogenesis. We have previously cloned and characterized FZD1, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, and FZD10. Here, we investigated expression profiles of all members of
Koji Ueno et al.
International journal of cancer, 132(8), 1731-1740 (2012-07-27)
Wnt signaling pathways play important roles in tumorigenesis and are initiated by binding of Wnt to various receptors including frizzleds (FZDs). FZDs are one of several families of receptors comprised of FZD/LRP/ROR2/RYK in the Wnt signaling pathway. Expression of some
Sze Chuen Cesar Wong et al.
PloS one, 8(11), e79481-e79481 (2013-11-21)
Frizzled homolog 3 receptor was up-regulated in several gastrointestinal cancers such as esophageal and gastric cancers. Moreover, frizzled homolog 3 has recently reported to be expressed in colorectal adenoma specimens. In the present study, we investigated the clinical significance of
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