F2762
Anti-Filamin antibody produced in goat
whole antiserum
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About This Item
MDL number:
UNSPSC Code:
12352203
Recommended Products
biological source
goat
conjugate
unconjugated
antibody form
whole antiserum
antibody product type
primary antibodies
clone
polyclonal
mol wt
antigen ~250 kDa
contains
15 mM sodium azide
species reactivity
chicken
technique(s)
indirect immunofluorescence: 1:40 using cultured chicken fibroblasts
western blot: suitable using total chicken gizzard extract
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
chicken ... FLNC(395260)
Specificity
The product shows a uniform labeling of filamin associated with microfilament bundles (stress fibers) and membrane ruffles of cultured cells.
Immunogen
filamin from chicken gizzard.
Application
Anti-Filamin antibody is suitable as a primary antibody in western blot analysis.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
Filamin, also known as actin-binding protein, is a large flexible V-shaped actin cross-linking protein present in vertebrates of both muscle and non-muscle cells. It has actin-binding domains at the ends of each arm. Filamin is a dimer of two large (280-kd) subunits, forming a flexible V-shaped molecule that crosslinks actin filaments into orthogonal networks. Filamin cross-links actin and promotes it′s aggregation and gelation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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P J Davies et al.
The Journal of biological chemistry, 253(11), 4036-4042 (1978-06-10)
Chicken gizzard filamin has been digested with purified Ca2+-activated protease. The subunits of (Mr = 250,000) of the protein are cleaved asymmetrically into two fragments, heavy merofilamin, Mr = 240,000, and light merofilamin, Mr = 9,500. Digestion is complete at
Structure and Organization of Actin Filaments
Cooper GM et al.
Cell (2000)
Yasuko Ono et al.
Biotechnology journal, 2(5), 565-576 (2007-03-22)
Calpain represents a family of Ca(2+)-dependent cytosolic cysteine proteases found in almost all eukaryotes and some bacteria, and is involved in a variety of biological phenomena, including brain function. Several substrates of calpain are aggressively proteolyzed under pathological conditions, e.g.
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