F1305

Anti-FEN-1 (C-terminal) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Flap endonuclease, Anti-Flap structure-specific endonuclease 1
• MDL number: MFCD09039190
• UNSPSC Code: 12352203

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen 45 kDa
• species reactivity: human
• concentration: ~1 mg/mL
• technique(s): immunoprecipitation (IP): 2-4 μg using HEK 293T cell lysates; indirect immunofluorescence: 5-10 μg/mL using paraformaldehyde-fixed HEK 293T cells; western blot: 0.5-1 μg/mL using K562 cell lysates
• UniProt accession no.: P39748
• shipped in: dry ice
• storage temp.: −20°C
• Gene Information: human ... FEN1(2237) ; mouse ... Fen1(14156) ; rat ... Fen1(84490)

Description

Immunogen

synthetic peptide corresponding to amino acids 367-380 of human FEN-1, conjugated to KLH via an N-terminal added cysteine residue. The corresponding sequence in rat and mouse differs by one and two amino acids, respectively.

Target description

FEN-1 (C-terminal) encodes a protein that removes 5′ overhanging flaps in DNA repair and processes the 5′ ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch b

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 12 - Non Combustible Liquids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)