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F1179

Sigma-Aldrich

FPL-55712

≥97% (HPLC), solid

Synonym(s):

7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]- 4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C27H29O9Na
CAS Number:
40786-08-1
Molecular Weight:
520.50
MDL number:
MFCD00068619
UNSPSC Code:
12352202
PubChem Substance ID:
329799675
NACRES:
NA.77

assay

≥97% (HPLC)

form

solid

color

off-white

mp

150-160 °C

solubility

H2O: ≥15 mg/mL, clear, yellow

storage temp.

−20°C

SMILES string

[Na+].CCCc1c(O)c(ccc1OCC(O)COc2ccc3C(=O)C=C(Oc3c2CCC)C([O-])=O)C(C)=O

InChI

1S/C27H30O9.Na/c1-4-6-19-22(10-8-17(15(3)28)25(19)31)34-13-16(29)14-35-23-11-9-18-21(30)12-24(27(32)33)36-26(18)20(23)7-5-2;/h8-12,16,29,31H,4-7,13-14H2,1-3H3,(H,32,33);/q;+1/p-1

InChI key

ZDEVPOBNLIVGFA-UHFFFAOYSA-M

Biochem/physiol Actions

CysLT1 leukotriene receptor antagonist.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
064K4605

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T Obata et al.
Life sciences, 52(12), PL97-P102 (1993-01-01)
The effect of a peptide leukotriene receptor antagonist ONO-1078 on the production of thromboxane (Tx) B2 induced by leukotriene (LT) D4 and antigen challenge was examined in guinea pig lungs. LTD4 (1-1,000 nM) induced a concentration-dependent production of TxB2 in
Leukotriene cysLT1 (LTD4) receptor antagonism of H1-antihistamines: an in vitro study.
M Q Zhang et al.
Inflammation research : official journal of the European Histamine Research Society ... [et al.], 46 Suppl 1, S93-S94 (1997-03-01)
A Shekher et al.
Methods and findings in experimental and clinical pharmacology, 19(4), 223-229 (1997-05-01)
The effects of FPL-55712 (leukotriene receptor antagonist) and OKY-046 (thromboxane synthase inhibitor) were studied on ischemic and reperfused myocardium using in vivo and in vitro rat heart paradigms. The in vivo studies included production of regional ischemia by coronary artery
M Pfeifer et al.
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie, 197(4), 177-187 (1997-01-01)
The pathophysiological role of endogenous leukotrienes in cardiovascular control and the regulation of renal function in congestive heart failure is not known. Therefore, in six conscious dogs with or without heart failure induced by right ventricular pacing (270/min, 10 days)
C M Rodríguez-Ortigosa et al.
Gastroenterology, 108(6), 1793-1801 (1995-06-01)
Cysteinyl-containing leukotrienes seem to exert a cholestatic effect. However, leukotriene inhibitors were found to reduce bile salt efflux in isolated rat hepatocytes, suggesting a role for leukotrienes in bile flow formation. In the isolated rat liver, the effects of two
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