F1177
Fluorescein hyaluronic acid
>95%, powder
Synonym(s):
Hyaluronic Acid Fluorescein Conjugate
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About This Item
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assay
>95%
form
powder
mol wt
~800,000 Da
color
orange
solubility
H2O: soluble 1 mg/mL
storage temp.
2-8°C
Application
Fluorescein hyaluronic acid has been used in the fluorescence imaging of hyaluronic acid (HA) and dextran surface coated filmsand patterned surfaces. It has also been used in confocal fluorescence microscopy to localize hyaluronic acid in collagen/HA composite gels .
Biochem/physiol Actions
Hyaluronan macromolecules (HAs) coupled to fluorescein amine is exploited to screen the hyaluronidase activity using fluorescence correlation spectroscopy (FCS) by measuring the quenching of fluorescein-labeled HA fragments. It binds on cell surface of malignant mesothelioma derived from human tumors.
Used to bind on cell surface of malignant mesothelioma derived from human tumors.
Other Notes
From cock′s comb or by fermentation.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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Rafal Fudala et al.
Journal of photochemistry and photobiology. B, Biology, 106, 69-73 (2011-11-16)
In this report we propose a lifetime-based sensing (LBS) for the detection of hyaluronidase (HA-ase). First, we heavily label hyaluronan macromolecules (HAs) with fluorescein amine. The fluorescein labeled HA (HA-Fl) has a weak fluorescence and short fluorescence lifetime due to
Hyaluronan receptors are expressed on human malignant mesothelioma cells but not on normal mesothelial cells
Asplund T and Heldin P
Cancer research, 54(16), 4516-4523 (1994)
Hyaluronan and dextran modified tubes resist cellular activation with blood contact
Eckmann DM, et al.
Colloids and Surfaces. B, Biointerfaces, 108, 44-51 (2013)
Rheology and confocal reflectance microscopy as probes of mechanical properties and structure during collagen and collagen/hyaluronan self-assembly
Yang Yl and Kaufman LJ
Biophysical Journal, 96(4), 1566-1585 (2009)
Human macrophage adhesion on polysaccharide patterned surfaces
Tsai IY, et al.
Soft Matter, 7(7), 3599-3606 (2011)
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