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EHU093241

Sigma-Aldrich

MISSION® esiRNA

targeting human DLC1

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About This Item

UNSPSC Code:
41105324
NACRES:
NA.51

description

Powered by Eupheria Biotech

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

TCCTGTTTGTTGAGGGTCTGTATTCATAGACCTTGACTGGAATATGTAAGACTGTGCAAAAAAAAAAAAAAAATTTATGTGTATTCTTATTCAAATTGCTTCTGAGAAGCAAAACTCTTTAAATACATTATGGAAGATAATGAAGATACTTCATTCTCTTGTGATATCAGTGTATGCGTACCTGTGTCGCTTTATTTGCAGTGTGTTGAGGGACTGGTGTATCCACTGGAATAGTTGGTACTCTTGGATGTGTTTTCTCACCAAGATGAGCAAAGAAAGGTTTGCACAGAGGAGTGTGAATGTGTGTTTGTTGCTGGCTGAATGGCAATAGATGTCTAAGGTGGATTCAGTGTCTGGCACACTGAGACACCTCCAA

Ensembl | human accession no.

ENSG00000164741

NCBI accession no.

NM_182643

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... DLC1(10395) , DLC1(10395)

Related Categories

General description

MISSION esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Yufei Liu et al.
Molecular and cellular biochemistry, 425(1-2), 47-58 (2016-11-11)
The heterogeneity of breast cancer makes it a challenging solid tumor to diagnose and treat. A tumor suppressor Deleted in Liver Cancer 1 (DLC1) has been reported to be down-regulated or even silenced in several kinds of cancer including breast
Ho-Suk Mun et al.
Scientific reports, 5, 17697-17697 (2015-12-08)
Understanding the mechanisms of memory formation is fundamental to establishing optimal educational practices and restoring cognitive function in brain disease. Here, we show for the first time in a non-primate species, that spatial learning receives a special bonus from self-directed
Yi-Ping Shih et al.
Biochimica et biophysica acta, 1853(12), 3258-3265 (2015-10-03)
DLC1 is a RhoGAP-containing tumor suppressor and many of DLC1's functions are absolutely dependent on its RhoGAP activity. Through its RhoGAP domain, DLC1 inhibits the activity of RhoA GTPase, which regulates actin cytoskeleton networks and dis/assembly of focal adhesions. Tensin1
Tomofumi Fujino et al.
The Journal of toxicological sciences, 40(4), 501-508 (2015-07-15)
Identification of substances with specific toxicity for carcinoma cells promises to facilitate the development of cancer chemotherapeutics that cause minimal side effects. Here, we show that knockdown of the farnesoid X receptor (FXR) effectively suppresses the proliferation of human hepatocellular

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