E9654
S1P4 C-Terminal Blocking Peptide
~1 mg/mL, buffered aqueous solution
Synonym(s):
EDG-6, Endothelial Cell Differentiation Gene 6
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About This Item
form
buffered aqueous solution
Quality Level
mol wt
~2.5 kDa
concentration
~1 mg/mL
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... S1PR4(8698)
General description
S1PR4 (sphingosine-1-phosphate receptor 4) is a member of the S1P or the Edg (endothelial differentiation gene) receptor family, which contains five members. It is a G-protein coupled receptor (GPCR). Its 3rd transmembrane domain contains a conserved glutamic acid residue.[1] It is expressed in lung, hematopoietic and lymphoid tissue.[2] This gene is localized to human chromosome 19p13.3.[3]
Biochem/physiol Actions
G protein-coupled receptor whose ligand might be a lysophospholipid or lysosphingo-lipid. Specifically expressed in fetal and adult lymphoid, hematopoietic and lung tissue.
S1PR4 (sphingosine-1-phosphate receptor 4) functions as a receptor for S1P, which is a phospholipid growth factor, and might control the transport of dendritic cells (DCs). Thus, it might promote Th2 lymphocyte-mediated immunity. S1P4 mediates RAS(rat sarcoma)-MAPK (mitogen-activated protein kinase) pathway by interacting with Gi/o proteins.[4] In ER (estrogen receptor)- breast cancer, its elevated expression is linked with decreased overall survival as well as disease-free survival.[5]
Physical form
Solution in phosphate buffered saline, pH 7.3.
Analysis Note
Used as a blocking peptide in immunoblotting applications with Anti-S1P4 polyclonal and monoclonal antibodies (Prod. Nos. E 7653, E 9529).
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Marco Idzko et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16(6), 625-627 (2002-03-29)
Sphingosine 1-phosphate (S1P) is a potent extracellular lysolipid phosphoric acid mediator that is released after IgE-stimulation of mast cells. Here we investigated the biological activity and intracellular signaling of S1P on human dendritic cells (DC), which are specialized antigen presenting
M H Gräler et al.
Genomics, 53(2), 164-169 (1998-10-29)
EDG receptors constitute a novel subfamily of G-protein-coupled receptors displaying a heterogeneous expression pattern. It was shown recently that the four members of this family thus far identified can bind lysophospholipids or lysosphingolipids as ligands. Here we report the identification
J Ohotski et al.
British journal of cancer, 106(8), 1453-1459 (2012-03-31)
We previously reported that sphingosine 1-phosphate receptor 4 (S1P(4)) is expressed and stimulates the ERK-1/2 pathway via a human epidermal growth factor receptor 2 (HER2)-dependent mechanism in oestrogen receptor-negative (ER(-)) MDA-MB-453 breast cancer cells. Clinical relevance of S1P(4) and sphingosine
Gill Holdsworth et al.
BMC biochemistry, 5, 12-12 (2004-08-10)
Sphingosine-1-phosphate and lysophosphatidic acid (LPA) are ligands for two related families of G protein-coupled receptors, the S1P and LPA receptors, respectively. The lysophospholipid ligands of these receptors are structurally similar, however recognition of these lipids by these receptors is highly
J R Van Brocklyn et al.
Blood, 95(8), 2624-2629 (2001-02-07)
EDG-6 is a recently cloned member of the endothelial differentiation gene (EDG) G protein-coupled receptor family that is expressed in lymphoid and hematopoietic tissue and in the lung. Homology of EDG-6 to the known sphingosine-1-phosphate (SPP) receptors EDG-1, EDG-3, and
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