E9538
Cytochrome P450 2C9 human
recombinant, expressed in Saccharomyces cerevisiae
Synonym(s):
Cytochrome P450 Microsome Preparation human, Cerosomes
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About This Item
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biological source
human
Quality Level
recombinant
expressed in Saccharomyces cerevisiae
form
liquid
specific activity
≥10 units/pmol enzyme (P450)
secondary activity
≥500 units/mg protein (Reductase activity)
concentration
≥10 mg/mL protein (Bradford)
1 pmol/μL (P450)
UniProt accession no.
application(s)
cell analysis
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CYP2C9(1559)
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General description
Microsome contents of CYP2C9 human and yeast CYP-reductase expressed in Saccharomyces cerevisiae.
Application
Recombinant cytochrome P450, isozyme 2C9, (CYP2C9) may be used in toxicity and drug metabolism/ pharmacokinetics research to identify its specificity and activity versus xenobiotic and endogenous compounds. Recombinant cytochrome P450, isozyme 2C9, may be used separately or as a component of a P450 isozyme panel to identify and characterize natural and synthetic selective inhibitors that affect the metabolism of toxic compounds or therapeutic drugs such as warfarin, bosentan, and fluoxetine.
Unit Definition
P450 Activity: One unit will oxidize 1 picomole of diclofenac per minute at pH 7.4 at 28 °C.
Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.
Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.
Physical form
50 mM Tris (pH 7.4), 1 mM EDTA, 20% glycerol
Other Notes
For more more information visit our drug metabolism resources for Cytochrome P450 microsome preparations.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Monika Langmajerová et al.
Electrophoresis, 36(11-12), 1365-1373 (2015-03-05)
A new CE-MS method with enzymatic reaction inside the capillary was developed for the study of drug metabolism by cytochromes P450. This automated method, based on the transverse diffusion of laminar flow profiles methodology, is comprised of the injection of
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