This understanding is correct, however, the stabilizer content is approximately 70%. The lot-specific Certificate of Analysis will provide the exact stabilizer content, which can then be used to calculate the amount of β-Estradiol 3-Sulfate.
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E9505
β-Estradiol 3-sulfate sodium salt
≥93%
Synonym(s):
1,3,5(10)-Estratriene-3,17β-diol 3-sulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-sulfate
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25 MG
$103.00
About This Item
Linear Formula:
C18H23O5SNa
CAS Number:
Molecular Weight:
374.43
MDL number:
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
sterility
non-sterile
Quality Level
assay
≥93%
form
powder
contains
~70% N-methyl-D-glucamine as stabilizer
solubility
methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
shipped in
ambient
storage temp.
room temp
SMILES string
[Na].[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24
InChI
1S/C18H24O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,17+,18+;;/m1../s1
InChI key
PYPVMTJYMKHIST-LBARCDFESA-N
General description
β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women.[1]
application
β-Estradiol 3-sulfate sodium salt has been used to measure the estradiol level from culture supernatant in ultra-performance liquid chromatography-tandem mass spectrometry.[2]
Biochem/physiol Actions
β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity.[3] β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy.[4] 17-β-Estradiol is the most active estrogen generated in our body.[5] During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.[6]
Packaging
Package size based on steroid content
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Rebeca Martin-Skilton et al.
Aquatic toxicology (Amsterdam, Netherlands), 79(1), 24-30 (2006-06-30)
We have characterized hepatic phenol sulfotransferase (SULT) activities in two benthic fish species, Mullus barbatus and Lepidorhombus boscii, using p-nitrophenol, dopamine, 17beta-estradiol, 4-nonylphenol, and 1-naphthol as substrates. High affinity sulfation of 17beta-estradiol was observed in both species (Km=28-75 nM), suggesting
Charles E Wood
Endocrinology, 152(12), 4966-4973 (2011-09-29)
Estradiol (E(2)) is an important modifier of the activity of the fetal hypothalamus-pituitary-adrenal axis. We have reported that estradiol-3-sulfate (E(2)SO(4)) circulates in fetal blood in far higher concentrations than E(2) and that the fetal brain expresses steroid sulfatase, required for
Frank F Scherr et al.
Environment international, 35(2), 291-297 (2008-08-13)
Estrogens-sulphates such as 17beta-estradiol-3-sulphate and estrone-3-sulphate are excreted by livestock in the urine. These conjugates are precursors to the free counterparts 17beta-estradiol and estrone, which are endocrine disrupting chemicals. In this study microcosm laboratory experiments were conducted in three pasture
Estrogen and the Vessel Wall, 38-38 (2003)
Meyler's Side Effects of Drugs: The International Encyclopedia of Adverse Drug Reactions and Interactions, 122-122 (2015)
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The description of the product says that it contains 70 % N-methyl-D-glucamine as a stabilizer. Does this mean that 1.0 mg of the powder contains 0.3 mg of β-Estradiol 3-sulfate and that I need to weigh in 3.33 mg of the powder to get 1 mg of substance?
1 answer-
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