E9038
Cytochrome P450 3A4 human
recombinant, expressed in Saccharomyces cerevisiae
Synonym(s):
Cytochrome P450 Microsome Preparation human, Cerosomes
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About This Item
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biological source
human
recombinant
expressed in Saccharomyces cerevisiae
form
liquid
specific activity
≥5 units/pmol enzyme
secondary activity
≥50 units/mg protein (Reductase activity)
concentration
≥5 mg/mL protein (Bradford)
1 pmol/μL
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... CYP3A4(1576)
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General description
Microsome contents of CYP3A4 human and CYP-reductase human expressed in Saccharomyces cerevisiae mixed with Cytochrome B5 human.
Unit Definition
P450 Activity: One unit will oxidize 1 picomole of testosterone per minute at pH 7.4 at 28 °C.
Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.
Reductase Activity: One unit will reduce 1 nanomole of cytochrome C per minute in the presence of NADPH at pH 7.4 at 28 °C.
Physical form
50 mM Tris (pH 7.4), 1 mM EDTA, 20% glycerol
Other Notes
For more more information visit our drug metabolism resources for Cytochrome P450 microsome preparations.
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Yicong Bian et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(9), 1336-1340 (2015-06-14)
Minipigs represent a good animal model because of the physiologic and anatomic similarities they share with humans. Three cytochrome P450 (CYP) 3A isozymes, CYP3A22, CYP3A29, and CYP3A46, have recently been reported to be expressed in Bama minipigs, which have limited
Haifeng Zhang et al.
PloS one, 10(6), e0128547-e0128547 (2015-06-06)
Human cytochrome b5 (Cyt b5) plays important roles in cytochrome P450 (CYP)-mediated drug metabolism. However, the expression level of Cyt b5 in normal human liver remains largely unknown. The effect of Cyt b5 on overall CYP activity in human liver
Scott Michaels et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(8), 1241-1251 (2014-05-13)
The CYP4F subfamily of enzymes has been identified recently to be involved in the metabolism of endogenous compounds (arachidonic acid and leukotriene B4), nutrients (vitamins K1 and E), and xenobiotics (pafuramidine and fingolimod). CYP4F2 and CYP4F3B are reported to be
John Eksterowicz et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1698-1707 (2014-07-31)
Cytochrome P450 4F12 is a drug-metabolizing enzyme that is primarily expressed in the liver, kidney, colon, small intestine, and heart. The properties of CYP4F12 that may impart an increased catalytic selectivity (decreased promiscuity) were explored through in vitro metabolite elucidation
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