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About This Item
Empirical Formula (Hill Notation):
C193H289N49O58S5
CAS Number:
Molecular Weight:
4383.98
MDL number:
UNSPSC Code:
12352200
assay
≥97% (HPLC)
form
solid
UniProt accession no.
storage temp.
−20°C
Gene Information
pig ... EDN1(396915)
Amino Acid Sequence
Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-His-Leu-Asp-Ile-Ile-Trp-Val-Asn-Thr-Pro-Glu-His-Ile-Val-Pro-Tyr-Gly-Leu-Gly-Ser-Pro-Ser-Arg-Ser [Disulfide Bridges: 1-15; 3-11]
Biochem/physiol Actions
Compared to ET-1, big endothelins show less vasoconstrictor activity in vitro but similar pressor effects in vivo
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Y Itoh et al.
FEBS letters, 231(2), 440-444 (1988-04-25)
A cDNA encoding a human endothelium-derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is
M Yanagisawa et al.
Nature, 332(6163), 411-415 (1988-03-31)
An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent vasoconstrictors known. Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional
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