E7902
EphA1/Fc Chimera human
recombinant, expressed in NSO cells, lyophilized powder
Synonym(s):
Eck, Eph
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About This Item
MDL number:
UNSPSC Code:
51111800
Recommended Products
biological source
human
recombinant
expressed in NSO cells
assay
>95% (SDS-PAGE)
form
lyophilized powder
mol wt
monomer calculated mol wt 84 kDa
~110 kDa by SDS-PAGE (reducing)
packaging
pkg of 200 μg
storage condition
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
technique(s)
ligand binding assay: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... EPHA1(2041)
General description
EphA1 (ephrin receptor A1) is a receptor tyrosine kinase (RTK), that belongs to the ephrin receptor family. It is the largest group of receptors in RTK family. This protein has extracellular domain containing the N-terminal, an α-helical single transmembrane region, and a cytoplasmic kinase domain containing the C-terminal. It was the first member of this family to be identified, and is localized to human chromosome. It has a wide range of tissue expression such as, thymus, lung, kidney, small intestinal, bladder, and colon.
Biochem/physiol Actions
EphA1 (ephrin receptor A1) has an essential role during development, and is involved in the guidance of axonal and cell migration in nervous system. Disruption of ephrin signaling might be involved in the tumorigenesis of clear cell renal cell carcinoma, and absence of EphA1 has a favorable prognosis in the same. It might also be involved in the tumorigenesis and progression of prostate cancer, and might have potential as a marker for prognosis, as well as a therapeutic target. Studies show that it reduces the risk of Alzheimer′s disease, by hindering pathological changes in brain areas such as, hippocampus, lateral occipitotemporal and inferior temporal gyri. In esophageal squamous cells, it acts as a differentiation marker. Its expression is elevated in esophageal squamous cell carcinoma, and this relates to advanced stage and metastasis to lymph node.
EphA1 is a member of the Eph receptor tyrosine kinase family shown to bind ephrin-A1; involved in pattern formation and morphogenesis.
Other Notes
Extracellular domain of human EphA1 (amino acids 1-547) fused by means of a polypeptide linker to the Fc region of human IgG1 that is histidine-tagged at the C-terminus.
Physical form
Lyophilized from a 0.2 μm filtered solution in Tris, pH 8.
Analysis Note
The biological activity is measured by its ability to bind recombinant mouse ephrin-A1/Fc in an ELISA assay.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Hui-Fu Wang et al.
Journal of Alzheimer's disease : JAD, 44(1), 115-123 (2014-09-04)
Ephrin type-A receptor 1 (EPHA1) (11771145) was documented to be one of the most strongly associated locus with Alzheimer's disease (AD) in a recent meta-analysis of five genome wide association studies. However, its contribution to the pathogenesis of AD remains
Matthieu Chavent et al.
Biochemistry, 53(42), 6641-6652 (2014-10-07)
EphA1 is a receptor tyrosine kinase (RTK) that plays a key role in developmental processes, including guidance of the migration of axons and cells in the nervous system. EphA1, in common with other RTKs, contains an N-terminal extracellular domain, a
Libo Peng et al.
International journal of clinical and experimental pathology, 6(9), 1854-1860 (2013-09-17)
The erythropoietin-producing hepatocellular (Eph) family of receptor tyrosine kinases regulates a multitude of physiological and pathological processes. EphA1 is the first member of Eph superfamily and is involved in carcinogenesis. The aim of this study was to investigate the expression
Jiandong Wang et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 121(1), 30-37 (2012-10-04)
Eph receptors play important roles in the development of cancer. The present study aimed to investigate the expression of EphA1 and its clinicopathologic significance in esophageal squamous cell carcinoma (ESCC). The expression levels of the EphA1 transcript and protein were
Marieta I Toma et al.
PloS one, 9(7), e102262-e102262 (2014-07-16)
The EPH receptor tyrosine kinases and their cell-bound ligands, the ephrins, have been shown to be associated with cancer development and progression. In this study, mRNA and protein expression of the receptors EPHA1 and EPHA2 as well as of their
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