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E7653

Sigma-Aldrich

Anti-S1P4, C-Terminal antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

Synonym(s):

Anti-EDG-6, Anti-Endothelial Cell Differentiation Gene 6

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About This Item

MDL number:
MFCD03454969
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

fractionated antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~45 kDa by SDS-PAGE

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: suitable

UniProt accession no.

O95977

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... S1PR4(8698)

Immunogen

synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-6/S1P4 receptor.

Application

Anti-S1P4, C-Terminal antibody produced in rabbit is suitable for western blotting at a working concentration of 5 to 10 μg/ml using COS cells transfected with full length EDG-6.

Biochem/physiol Actions

Sphingosine-1-phosphate receptor 4 (S1PR4, EDG-6) is a human gene which encodes a G protein-coupled receptor and is identified as an orphan G-protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P). EDG-6 is a member of the endothelial differentiation gene (EDG) G protein-coupled receptor family. It is expressed in lymphoid, hematopoietic tissue and in the lung. EDG-6 acts as a high affinity receptor for SPP that couples to a G(i/o) protein leading to the activation of growth-related signaling pathways. It is one of the S1P or lysosphingolipid receptors that couples to phospholipase C-Ca2+ system through pertussis toxin-sensitive G-proteins.

Physical form

Supplied in phosphate buffered saline, pH 7.3, and 0.08% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

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Certificates of Analysis (COA)

Lot/Batch Number
101K0339

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Y Yamazaki et al.
Biochemical and biophysical research communications, 268(2), 583-589 (2000-02-19)
The endothelial differentiation gene-6 (Edg-6) was recently identified as an orphan G-protein-coupled receptor. Its predicted amino acid sequence is very close to Edg family of receptor proteins whose ligand is supposed to be lysophosphatidic acid (LPA) or lysosphingolipid such as
J R Van Brocklyn et al.
Blood, 95(8), 2624-2629 (2001-02-07)
EDG-6 is a recently cloned member of the endothelial differentiation gene (EDG) G protein-coupled receptor family that is expressed in lymphoid and hematopoietic tissue and in the lung. Homology of EDG-6 to the known sphingosine-1-phosphate (SPP) receptors EDG-1, EDG-3, and

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