E7534

Anti-Endoglin antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-CD105, Anti-END, Anti-ENG, Anti-HHT1, Anti-ORW, Anti-ORW1
• UNSPSC Code: 51111800
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 200
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• mol wt: antigen ~95 kDa
• species reactivity: human
• concentration: ~1.0 mg/mL
• technique(s): western blot: 1-2 μg/mL using HEK-293T cell lysates over-expressing human endoglin
• UniProt accession no.: P17813
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... ENG(2022)

Description

General description

Endoglin (CD105) is a membrane glycoprotein that acts as auxillary receptor for TGF-β and is expressed on proliferating vascular endothelial cells. Alternatively spliced isoforms, long endoglin, short endoglin and soluble endoglin are present but the long isoform is predominantly expressed.The major biological functions of endoglin are in angiogenesis and vascular development and homeostasis. It is also vital for wound healing and in development of embryo. Overexpression of endoglin is reported in solid tumors and inflammatory tissues. Expression of endoglin in solid tumors negatively correlates to survival and metastasis and is considered a marker for good prognosis in a variety of solid tumors
Anti-Endoglin specifically recognizes human endoglin (~95 kDa).

Application

Anti-Endoglin antibody may be used for immunoblotting at a working concentration of 1.0-2.0 μg/ml using whole cell lysates of HEK-293T cells over-expressing human endoglin.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.