Recommended Products
biological source
human skin
Quality Level
form
powder
technique(s)
ligand binding assay: suitable
UniProt accession no.
storage temp.
2-8°C
InChI
1S/C27H48N6O6/c1-9-17(6)23(32-24(36)19(13-15(2)3)30-18(7)34)26(38)29-14-21(35)31-22(16(4)5)27(39)33-12-10-11-20(33)25(37)28-8/h15-17,19-20,22-23H,9-14H2,1-8H3,(H,28,37)(H,29,38)(H,30,34)(H,31,35)(H,32,36)/t17-,19-,20-,22-,23-/m0/s1
InChI key
DPUYCSDGMSDKKV-MKBYFEBXSA-N
Gene Information
human ... ELN(2006)
General description
Elastin is an extracellular matrix protein encoded by the gene ELN, which is mapped to human chromosome 7q11.23.[1] Elastin is a major protein component of elastic fibres and is synthesized from the precursor protein called tropoelastin.[2] Elastin is present in all the vertebrates except for the primitive fish. Elastin is majorly composed of glycine, proline and other hydrophobic residues.[3]
Application
Elastin from human skin has been used as a substrate for the enzyme reaction with age-related NADH oxidase (arNOX) using fluorescein-conjugated tyramine.[4]
Elastin is a structural protein which has been used in studies of chronic obstructive pulmonary disease (COPD). It may be used to investigate why there is a lack of repair for these proteins in patients with COPD.
Biochem/physiol Actions
Elastin is essential for resilience of arteries, and other elastic tissues like lungs and skin.[2] Polymorphism in ELN gene causes intracranial aneurysm.[1] Loss of function or haploinsufficiency of ELN gene leads to supravalvular aortic stenosis (SVAS).[2] Frameshift mutations in ELN gene is implicated in congenital cutis laxa resulting in skin laxity and affect pulmonary and cardiovascular system.[5]
Preparation Note
Prepared under mild extraction conditions to minimize peptide bond cleavage as described by Starcher, et al.[6]
Analysis Note
Final purity determined by amino acid analysis and the percent insoluble residue remaining after digestion with porcine elastase.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Genetic Risk Assessment of Elastin Gene Polymorphisms with Intracranial Aneurysm in Koreans
Jeon JP, et al.
Neurologia Medico-Chirurgica, 58(1), 17-22 (2018)
Cutis laxa arising from frameshift mutations in exon 30 of the elastin gene (ELN)
Zhang MC, et al.
The Journal of biological chemistry, 274(2), 981-986 (1999)
Elastin: relation of protein and gene structure to disease.
Rosenbloom J
Laboratory Investigation; a Journal of Technical Methods and Pathology, 51(6), 605-623 (1984)
Z Urbán et al.
Human genetics, 106(6), 577-588 (2000-08-15)
We have used single-strand conformation and heteroduplex analyses of genomic amplimers to identify point mutations within the elastin gene (ELN) in patients with non-syndromic supravalvular aortic stenosis (SVAS) from a total of eight unrelated families. Six novel point mutations were
Purification and comparison of elastins from different animal species.
B C Starcher et al.
Analytical biochemistry, 74(2), 441-447 (1976-08-01)
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