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E7278

Sigma-Aldrich

Anti-S1P2, C-Terminal antibody produced in rabbit

~1 mg/mL, fractionated antiserum, buffered aqueous solution

Synonym(s):

Anti-EDG-5, Anti-Endothelial Cell Differentiation Gene 5

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About This Item

MDL number:
MFCD02686109
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

fractionated antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~42 kDa by SDS-PAGE

species reactivity

human

concentration

~1 mg/mL

technique(s)

western blot: suitable

UniProt accession no.

O95136

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... S1PR2(9294)

Immunogen

synthetic peptide (approximately 2.5 kDa, native) derived from the C-terminal region of the EDG-5/S1P2 receptor.

Application

Anti-S1P2, C-Terminal antibody produced in rabbit is suitable for western blotting.

Biochem/physiol Actions

Sphingosine-1-phosphate receptor 2 (S1PR2 or S1P2) is a human gene encodeing a G protein-coupled receptor. It binds the lipid signaling molecule sphingosine 1-phosphate (S1P) and regulates vascular permeability along with S1P1. Activation of S1P2R in endothelial cells increases vascular permeability. It is a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses. S1P acts as an intercellular mediator by interacting with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. S1P2 receptor is involved in S1P-induced platelet aggregation and Rho kinase activation. Type 2 diabetes patient responds to S1P.

Physical form

Supplied in phosphate buffered saline, pH 7.3, containing 0.08% sodium azide.

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Storage Class

10 - Combustible liquids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Voahanginirina Randriamboavonjy et al.
Basic research in cardiology, 104(3), 333-340 (2009-01-14)
Sphingosine-1-phosphate (S1P) is known to affect platelet responsiveness but the receptor mediating these effects and the mechanisms involved are poorly understood. This study was undertaken to examine S1P receptor expression in human platelets as well as potential changes associated with
Teresa Sanchez et al.
Arteriosclerosis, thrombosis, and vascular biology, 27(6), 1312-1318 (2007-04-14)
S1P acts via the S1PR family of G protein-coupled receptors to regulate a variety of physiological responses. Whereas S1P1R activates G(i)- and PI-3-kinase-dependent signals to inhibit vascular permeability, the related S1P2R inhibits the PI-3-kinase pathway by coupling to the Rho-dependent
Makoto Osada et al.
Biochemical and biophysical research communications, 299(3), 483-487 (2002-11-26)
Sphingosine 1-phosphate (Sph-1-P), a bioactive lysophospholipid capable of inducing a wide spectrum of biological responses, acts as an intercellular mediator, through interaction with the endothelial differentiation gene (EDG)/S1P family of G protein-coupled receptors. In this study, the effects of JTE-013

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